Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera

Authors :: Will Roeffen
Wijnand Eling
Bert Mulder
T. Lensen
P. J. A. Beckers
J. H. E. T. Meuwissen
Robert W. Sauerwein
Karina Teelen
Source :: Memórias do Instituto Oswaldo Cruz., Vol 89, Pp 13-15 (1994), Memórias do Instituto Oswaldo Cruz, Volume: 89 Supplement 2, Pages: 13-15, Published: 1994
Publication Year :: 1994
Publisher :: Instituto Oswaldo Cruz, Ministério da Saúde, 1994.
Abstract: Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55% of the sera blocking in the bio-assay gave positive results in these competition ELISA's.

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