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Efficacy of Bilevel-auto Treatment in Patients with Obstructive Sleep Apnea Not Responsive to or Intolerant of Continuous Positive Airway Pressure Ventilation
- Source :
- Journal of Clinical Sleep Medicine. 11:981-985
- Publication Year :
- 2015
- Publisher :
- American Academy of Sleep Medicine (AASM), 2015.
-
Abstract
- Ventilation with continuous positive airway pressure (CPAP) is the gold standard therapy for obstructive sleep apnea (OSA). However, it was recently suggested that a novel mode of ventilation, Bilevel-auto, could be equally effective in treating patients unable to tolerate CPAP. The aim of this study was to investigate the ability of Bilevel-auto to treat OSA patients whose nocturnal ventilatory disturbances are not completely corrected by CPAP.We enrolled 66 consecutive OSA patients, not responsive to (group A) or intolerant of (group B) CPAP treatment, after a full night of manual CPAP titration in a laboratory. Full polysomnography data and daytime sleepiness score were compared for each group in the three different conditions: basal, during CPAP, and during Bilevel-auto.The apnea-hypopnea index decreased significantly during CPAP in both groups; however, in the group A, there was a further significant improvement during Bilevel-auto. The same trend was observed for oxygenation indices, while the distribution and the efficiency of sleep did not differ following the switch from CPAP to Bilevel-auto.This study confirmed the role of Bilevel-auto as an effective therapeutic alternative to CPAP in patients intolerant of this latter mode of ventilation. Moreover, extending the use of Bilevel-auto to those OSA patients not responsive to CPAP, we showed a significantly better correction of nocturnal respiratory disturbances.
- Subjects :
- Male
Pulmonary and Respiratory Medicine
Polysomnography
medicine.medical_treatment
Bilevel-auto
COPD
CPAP
Noninvasive ventilation
Obesity
Sleep
Sleep apnea
medicine
Humans
In patient
Continuous positive airway pressure
Sleep Apnea, Obstructive
Continuous Positive Airway Pressure
business.industry
Middle Aged
medicine.disease
Respiration, Artificial
Scientific Investigations
nervous system diseases
respiratory tract diseases
Obstructive sleep apnea
Treatment Outcome
Neurology
Anesthesia
Breathing
Female
Sleep Stages
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 15509397 and 15509389
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Sleep Medicine
- Accession number :
- edsair.doi.dedup.....f61faae38ed2334bac1f1fd5c801579a