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The Immunomodulatory Functions of Butyrate
- Source :
- Journal of Inflammation Research
- Publication Year :
- 2021
- Publisher :
- Informa UK Limited, 2021.
-
Abstract
- The gastrointestinal (GI) system contains many different types of immune cells, making it a key immune organ system in the human body. In the last decade, our knowledge has substantially expanded regarding our understanding of the gut microbiome and its complex interaction with the gut immune system. Short chain fatty acids (SCFA), and specifically butyrate, play an important role in mediating the effects of the gut microbiome on local and systemic immunity. Gut microbial alterations and depletion of luminal butyrate have been well documented in the literature for a number of systemic and GI inflammatory disorders. Although a substantial knowledge gap exists requiring the need for further investigations to determine cause and effect, there is heightened interest in developing immunomodulatory therapies by means of reprogramming of gut microbiome or by supplementing its beneficial metabolites, such as butyrate. In the current review, we discuss the role of endogenous butyrate in the inflammatory response and maintaining immune homeostasis within the intestine. We also present the experimental models and human studies which explore therapeutic potential of butyrate supplementation in inflammatory conditions associated with butyrate depletion.
- Subjects :
- Immunology
gut microbiome
Inflammation
Review
Butyrate
Biology
Gut flora
Immune system
inflammatory bowel disease
Immunity
medicine
Immunology and Allergy
innate immunity
Innate immune system
gut microbiota
dysbiosis
adaptive immunity
butyrate
medicine.disease
Acquired immune system
biology.organism_classification
immunity
inflammation
epithelial barrier
medicine.symptom
short chain fatty acids
Dysbiosis
Subjects
Details
- ISSN :
- 11787031
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of Inflammation Research
- Accession number :
- edsair.doi.dedup.....f6146902edff494430451a4d673c7f81
- Full Text :
- https://doi.org/10.2147/jir.s300989