Back to Search
Start Over
Extracellular volume fraction by T1 mapping predicts improvement of left ventricular ejection fraction after catheter ablation in patients with non-ischemic dilated cardiomyopathy and atrial fibrillation
- Source :
- The International Journal of Cardiovascular Imaging. 37:2535-2543
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Absence of myocardial fibrosis on late gadolinium enhanced (LGE) magnetic resonance imaging (MRI) is associated with improvement of left ventricular systolic function after catheter ablation (CA) for atrial fibrillation (AF) with non-ischemic dilated cardiomyopathy (NIDCM). Extracellular volume fraction (ECV) by T1 mapping has emerges as a non-invasive mean to quantify severity of myocardial fibrosis. The aim of this study was to assess the incremental value of ECV over LGE-MRI for the improvement of LVEF(∆EF) after CA in NIDCM patients. A total of thirty-two patients with NIDCM and AF (mean age 67.4 ± 9.3 years; 29 (91%) male) were retrospectively studied. Using a 1.5 T MR scanner and 32 channel cardiac coils, LGE-MRI, pre- and post-T1 mapping images of LV wall at mid-ventricular level (modified look-locker inversion recovery sequence) were acquired. All patients successfully underwent CA for AF, and the improvement of LVEF after CA were evaluated by echocardiography. All patients restored sinus rhythm after CA at the time of echocardiography. The mean LVEF was 35.1 ± 9.7% before CA and 52.2 ± 10.2% after CA (p 0.001), resulting an increase of 17.4 ± 12.6%. Significant correlation was found between ∆LVEF and % LGE (r = - 0.49, p = 0.004), ∆LVEF and extracellular volume fraction (ECV) (r = - 0.47, p = 0.010). Area under the receiver operating characteristics curve (AUC) of combination of %LGE and ECV for predicting improvement of LVEF 10% was substantially higher than that of %LGE alone (AUC: 0.830 vs 0.602). In NIDCM patients with AF, ECV had incremental value over %LGE for predicting improvement of EF by CA, suggesting that the assessment of diffuse interstitial fibrosis may be important to forecast the response of CA.
- Subjects :
- Cardiomyopathy, Dilated
Male
medicine.medical_specialty
medicine.medical_treatment
Contrast Media
Magnetic Resonance Imaging, Cine
Catheter ablation
030204 cardiovascular system & hematology
Ventricular Function, Left
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Predictive Value of Tests
Internal medicine
Atrial Fibrillation
Humans
Medicine
Radiology, Nuclear Medicine and imaging
Sinus rhythm
cardiovascular diseases
Cardiac imaging
Aged
Retrospective Studies
Ejection fraction
medicine.diagnostic_test
business.industry
Myocardium
Stroke Volume
Dilated cardiomyopathy
Magnetic resonance imaging
Atrial fibrillation
medicine.disease
Catheter Ablation
Cardiology
Myocardial fibrosis
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15730743 and 15695794
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- The International Journal of Cardiovascular Imaging
- Accession number :
- edsair.doi.dedup.....f60f9f787769f8fe5cfafcc134b31ecd