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Clinical phenotypes of primary hyperparathyroidism in hospitalized patients who underwent parathyroidectomy
- Source :
- Endocrine Connections, Endocrine Connections, Vol 10, Iss 2, Pp 248-255 (2021)
- Publication Year :
- 2021
- Publisher :
- Bioscientifica, 2021.
-
Abstract
- Objective The aim of our study was to investigate the distribution of the PHPT clinical manifestations and biochemical features in patients who underwent parathyroidectomy. Materials and methods Medical records of 449 patients from three Medical Centers (Saint-Petersburg, Russia), hospitalized during a period from 2011 to 2018, were reviewed. History and anthropometric data, laboratory results (iPTH, total and iCa, phosphorus, ALP, 24-h urinary calcium, 25(OH)D) and imaging data (ultrasonography, scintigraphy, CT/MRI scan, DXA) were analyzed. Results Three hundred ninety-four patients were included in the final analysis. Median age was 60 years with 94.2% being women. Symptomatic disease was evident in 222 (56.4%) patients, asymptomatic in 172 (43.6%). Skeletal involvement was more common for women, while frequency of other manifestations did not differ in both genders. There was no difference between symptomatic and asymptomatic patients in age. Serum iPTH level was higher in symptomatic patients (202.9 and 181.0 pg/mL, P = 0.022). Serum 25(OH)D level was estimated in few patients and negatively correlated with PTH (r = ¯0.294, P = 0.005), iCa (r = ¯0.268, P = 0.010) and total Ca (r = ¯0.284, P = 0.014) levels. Manifestations of CVD were observed in 67.7% of cases and affected equally both symptomatic and asymptomatic patients (70.7 and 63.4%, P = 0.076). Both age and BMI were higher in patients with CVD, whether or not they were symptomatic (62 and 53 years, P < 0.0001; 30.4 vs 26.0 kg/m2, P < 0.0001, respectively). Conclusions This experience illustrates that symptomatic phenotype is still the most common form of PHPT.
- Subjects :
- Parathyroidectomy
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
vitamin D
030209 endocrinology & metabolism
030204 cardiovascular system & hematology
Scintigraphy
lcsh:Diseases of the endocrine glands. Clinical endocrinology
parathyroid gland
Gastroenterology
Asymptomatic
03 medical and health sciences
0302 clinical medicine
Endocrinology
Internal medicine
Internal Medicine
medicine
Vitamin D and neurology
parathyroid hormone
primary hyperparathyroidism
lcsh:RC648-665
medicine.diagnostic_test
business.industry
Research
Medical record
hypercalcemia
medicine.disease
Urinary calcium
medicine.anatomical_structure
Parathyroid gland
medicine.symptom
business
Primary hyperparathyroidism
Subjects
Details
- ISSN :
- 20493614
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Endocrine Connections
- Accession number :
- edsair.doi.dedup.....f5f8a9053040f84b23a742e14fc78ea7