Tissue apoptosis in mice infected with Leptospira interrogans serovar Icterohaemorrhagiae

Made available in DSpace on 2015-12-07T15:32:03Z (GMT). No. of bitstreams: 0 Previous issue date: 2015. Added 1 bitstream(s) on 2015-12-07T15:52:46Z : No. of bitstreams: 1 PMC4517494.pdf: 1805761 bytes, checksum: 6cf8d72c78632ac401cdaaf2338314de (MD5) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) This investigation aimed to evaluate the occurrence of some apoptotic features induced by Leptospira interrogans serovar Icterohaemorrhagiae infection in young BALB/c mice during 2, 4, 7, 10, 14 and 21 days post-infection (dpi). The animals were euthanized and lung, liver and kidneys were harvested to histopathology analysis and immunohistochemistry to caspase-3 antigen detection was performed. Chromatin condensation in kidney and liver tissues, but not in lung tissue, was observed. Caspase-3 reactive cells, mainly characterized as renal epithelial cells, were detected in the days 14 and 21 at high levels when compared to days 2, 4 and 7 (p = 0.025; p