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Temporal analysis of intratumoral metabolic heterogeneity characterized by textural features in cervical cancer
- Source :
- European journal of nuclear medicine and molecular imaging. 40(5)
- Publication Year :
- 2012
-
Abstract
- The aim of this pilot study was to explore heterogeneity in the temporal behavior of intratumoral [18F]fluorodeoxyglucose (FDG) accumulation at a regional scale in patients with cervical cancer undergoing chemoradiotherapy. Included in the study were 20 patients with FIGO stages IB1 to IVA cervical cancer treated with combined chemoradiotherapy. Patients underwent FDG PET/CT before treatment, during weeks 2 and 4 of treatment, and 12 weeks after completion of therapy. Patients were classified based on response to therapy as showing a complete metabolic response (CMR), a partial metabolic response (PMR), or residual disease and the development of new disease (NEW). Based on the presence of residual primary tumor following therapy, patients were divided into two groups, CMR and PMR/NEW. Temporal profiles of intratumoral FDG heterogeneity as characterized by textural features at a regional scale were assessed and compared with those of the standardized uptake value (SUV) indices (SUVmax and SUVmean) within the context of differentiating response groups. Textural features at a regional scale with emphasis on characterizing contiguous regions of high uptake in tumors decreased significantly with time (P
- Subjects :
- Adult
medicine.medical_specialty
Time Factors
Uterine Cervical Neoplasms
Standardized uptake value
Context (language use)
Article
Fluorodeoxyglucose F18
medicine
Humans
Radiology, Nuclear Medicine and imaging
Cervix
Aged
Neoplasm Staging
Cervical cancer
Fluorodeoxyglucose
medicine.diagnostic_test
business.industry
General Medicine
Chemoradiotherapy
Middle Aged
medicine.disease
Primary tumor
medicine.anatomical_structure
Treatment Outcome
Positron emission tomography
Positron-Emission Tomography
Female
Radiology
Nuclear medicine
business
medicine.drug
Subjects
Details
- ISSN :
- 16197089
- Volume :
- 40
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- European journal of nuclear medicine and molecular imaging
- Accession number :
- edsair.doi.dedup.....f5f119fc90370851ae1347c532fd9687