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Decreased iron burden in overweight C282Y homozygous women: Putative role of increased hepcidin production
- Source :
- Hepatology, Hepatology, 2013, 57 (5), pp.1784-92. ⟨10.1002/hep.26261⟩, Hepatology, Wiley-Blackwell, 2013, 57 (5), pp.1784-92. ⟨10.1002/hep.26261⟩
- Publication Year :
- 2013
- Publisher :
- HAL CCSD, 2013.
-
Abstract
- International audience; An excess of visceral adipose tissue could be involved as a modulator of the penetrance of HFE hemochromatosis since fat mass is associated with overexpression of hepcidin and low transferrin saturation was found to be associated with being overweight in women. This study was aimed at assessing the relationship between body mass index (BMI), a surrogate marker of insulin resistance, and iron burden in HFE hemochromatosis. In all, 877 patients from a cohort of C282Y homozygotes were included in the study when BMI at diagnosis and amount of iron removed (AIR) by phlebotomy were available. No relationship between AIR and BMI was found in men, whereas 15.1% (52/345) of women with AIR
- Subjects :
- Male
Comorbidity
Overweight
Body Mass Index
Cohort Studies
0302 clinical medicine
Phlebotomy
2. Zero hunger
chemistry.chemical_classification
0303 health sciences
biology
Homozygote
Transferrin
Middle Aged
3. Good health
030220 oncology & carcinogenesis
Female
Hemochromatosis
medicine.symptom
Adult
medicine.medical_specialty
Iron
03 medical and health sciences
Insulin resistance
Hepcidins
Hepcidin
Internal medicine
medicine
Humans
Hemochromatosis Protein
Retrospective Studies
030304 developmental biology
Hepatology
Transferrin saturation
business.industry
Histocompatibility Antigens Class I
Membrane Proteins
nutritional and metabolic diseases
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
medicine.disease
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Endocrinology
chemistry
Case-Control Studies
Ferritins
Multivariate Analysis
biology.protein
Insulin Resistance
business
Body mass index
Antimicrobial Cationic Peptides
Subjects
Details
- Language :
- English
- ISSN :
- 02709139 and 15273350
- Database :
- OpenAIRE
- Journal :
- Hepatology, Hepatology, 2013, 57 (5), pp.1784-92. ⟨10.1002/hep.26261⟩, Hepatology, Wiley-Blackwell, 2013, 57 (5), pp.1784-92. ⟨10.1002/hep.26261⟩
- Accession number :
- edsair.doi.dedup.....f5f0794307146ab14b66808988b67c4b