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Spanish validation of Charlson index applied to prostate cancer
- Source :
- Clinical and Translational Oncology. 22:1187-1192
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Comorbidity assessment is essential in the triage of care for men with prostate cancer (PC). The aim of this study was to validate the Spanish version of the revised Charlson index (RCI) in PC. 731 PC patients diagnosed from 1993 to 2008 were referred to our Radiation Oncology Department. The RCI classified patients into four categories RCI 0, RCI 1–2, RCI 3–4, and RCI 5 and higher. The Kaplan–Meier method and Cox proportional hazards modeling were used. We also analyzed the median age of patients who remained alive at the last control and those who died due to non-prostate cancer comorbidities. 636 patients were included median age: 70 years (44–85). The mean follow-up was 153.62 months, (6–288 months). Distribution of the D’Amico risk classification was 21%, 38.2%, and 40.8% for low, intermediate, and high risk, respectively. The RCI distribution categories were: 303 (46.7%) RCI 0, 102 (16%) RCI 1–2, 131 (20.6%) RCI 3–4, and 100 (15.7%) RCI 5 and higher. The probability of non-cause-specific mortality at 5 and 10 years was 2. 4% and 11.25% RCI 0, 3 and 14.1% RCI 1–2, 5.7% and 22.1% RCI 3–4, and 47% and 92% (RCI 5 and higher). The median age in the last control in patients alive or who had died by non-PC causes was 82.81 years (55.27–102). The RCI may be used to aid medical decision making in older Spanish men with PC, especially in those with a high RCI 5 and higher.
- Subjects :
- Adult
Male
0301 basic medicine
Cancer Research
medicine.medical_specialty
Clinical Decision-Making
Charlson index
Comorbidity
Kaplan-Meier Estimate
03 medical and health sciences
Prostate cancer
Life Expectancy
0302 clinical medicine
Risk Factors
Cause of Death
Internal medicine
Radiation oncology
medicine
Humans
In patient
Mortality
Aged
Proportional Hazards Models
Aged, 80 and over
business.industry
Proportional hazards model
Prostatic Neoplasms
Reproducibility of Results
General Medicine
Middle Aged
Medical decision making
Prognosis
medicine.disease
030104 developmental biology
Oncology
Spain
030220 oncology & carcinogenesis
business
Risk classification
Subjects
Details
- ISSN :
- 16993055 and 1699048X
- Volume :
- 22
- Database :
- OpenAIRE
- Journal :
- Clinical and Translational Oncology
- Accession number :
- edsair.doi.dedup.....f5ebb36538961ee525e4c05aa3918a39