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Bacillus cereus bacteraemia: comparison between haematologic and nonhaematologic patients

Bacillus cereus bacteraemia: comparison between haematologic and nonhaematologic patients

Authors :
Guy Prod'hom
R. Meuli
L. Senn
Pierre-Yves Bochud
Stefano Giulieri
S. Tusgul
Source :
New microbes and new infections, vol. 15, pp. 65-71, New Microbes and New Infections, Vol 15, Iss C, Pp 65-71 (2017), New Microbes and New Infections
Publication Year :
2017
Publisher :
Elsevier BV, 2017.

Abstract

Bacillus cereus bacteraemia can be severe, especially among patients with haematologic malignancy. We retrospectively reviewed first episodes of true B. cereus bacteraemia (more than one positive bottle plus signs of infection) at our institution between 1997 and 2013 with the aim to compare haematologic versus nonhaematologic patients and analyse episodes with complicated outcome. Among 56 episodes of positive-blood cultures for B. cereus, 21 were considered significant. Median age was 54 years (range 23–82 years). Ten patients (48%) had a haematologic malignancy; all were neutropenic at the time of B. cereus bacteraemia. Nonhaematologic patients were either intravenous drug users (n = 3, 14%), polytraumatized (n = 3, 14%) or had multiple chronic comorbidities (n = 5, 24%). Most episodes were hospital acquired (15, 71%). Sources of bacteraemia were intravascular catheter (n = 11, 52%), digestive tract (n = 6, 29%), drug injection (n = 3, 14%) and wound (n = 1, 5%). Adequate antibiotic therapy was provided to 18 patients (86%) during a median of 17 days (range 2–253 days). The intravascular catheter was removed in eight cases (42%). Three haematologic patients had a complicated course with neurologic complications (meningoencephalitis and cerebral abscesses). Complications appeared to be associated with catheter infection (100% of complicated cases vs. 29% of noncomplicated cases). In conclusion, B. cereus bacteraemia can have a complicated course in a subset of patients, mainly those with haematologic malignancy. Catheter infection may be associated with a worse outcome with frequent neurologic complications.

Details

ISSN :
20522975
Volume :
15
Database :
OpenAIRE
Journal :
New Microbes and New Infections
Accession number :
edsair.doi.dedup.....f5de2d53182e7636288ccdc4a5695e1e
Full Text :
https://doi.org/10.1016/j.nmni.2016.11.011