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Bacillus cereus bacteraemia: comparison between haematologic and nonhaematologic patients
Bacillus cereus bacteraemia: comparison between haematologic and nonhaematologic patients
- Source :
- New microbes and new infections, vol. 15, pp. 65-71, New Microbes and New Infections, Vol 15, Iss C, Pp 65-71 (2017), New Microbes and New Infections
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Bacillus cereus bacteraemia can be severe, especially among patients with haematologic malignancy. We retrospectively reviewed first episodes of true B. cereus bacteraemia (more than one positive bottle plus signs of infection) at our institution between 1997 and 2013 with the aim to compare haematologic versus nonhaematologic patients and analyse episodes with complicated outcome. Among 56 episodes of positive-blood cultures for B. cereus, 21 were considered significant. Median age was 54 years (range 23–82 years). Ten patients (48%) had a haematologic malignancy; all were neutropenic at the time of B. cereus bacteraemia. Nonhaematologic patients were either intravenous drug users (n = 3, 14%), polytraumatized (n = 3, 14%) or had multiple chronic comorbidities (n = 5, 24%). Most episodes were hospital acquired (15, 71%). Sources of bacteraemia were intravascular catheter (n = 11, 52%), digestive tract (n = 6, 29%), drug injection (n = 3, 14%) and wound (n = 1, 5%). Adequate antibiotic therapy was provided to 18 patients (86%) during a median of 17 days (range 2–253 days). The intravascular catheter was removed in eight cases (42%). Three haematologic patients had a complicated course with neurologic complications (meningoencephalitis and cerebral abscesses). Complications appeared to be associated with catheter infection (100% of complicated cases vs. 29% of noncomplicated cases). In conclusion, B. cereus bacteraemia can have a complicated course in a subset of patients, mainly those with haematologic malignancy. Catheter infection may be associated with a worse outcome with frequent neurologic complications.
- Subjects :
- 0301 basic medicine
bacteraemia
medicine.medical_specialty
030106 microbiology
Neutropenia
Microbiology
lcsh:Infectious and parasitic diseases
03 medical and health sciences
0302 clinical medicine
Bacillus cereus
Antibiotic therapy
medicine
neutropenia
lcsh:RC109-216
030212 general & internal medicine
Drug injection
intravascular catheter
Intravenous drug
business.industry
Meningoencephalitis
central nervous system
medicine.disease
Surgery
Catheter
Infectious Diseases
Intravascular catheter
Original Article
Digestive tract
business
Subjects
Details
- ISSN :
- 20522975
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- New Microbes and New Infections
- Accession number :
- edsair.doi.dedup.....f5de2d53182e7636288ccdc4a5695e1e
- Full Text :
- https://doi.org/10.1016/j.nmni.2016.11.011