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Contrast-enhanced 3T MR Perfusion of Musculoskeletal Tumours: T1 Value Heterogeneity Assessment and Evaluation of the Influence of T1 Estimation Methods on Quantitative Parameters
- Source :
- European Radiology, European Radiology, Springer Verlag, 2017, 27 (12), pp.4903-4912. ⟨10.1007/s00330-017-4891-z⟩
- Publication Year :
- 2017
-
Abstract
- To evaluate intra-tumour and striated muscle T1 value heterogeneity and the influence of different methods of T1 estimation on the variability of quantitative perfusion parameters. Eighty-two patients with a histologically confirmed musculoskeletal tumour were prospectively included in this study and, with ethics committee approval, underwent contrast-enhanced MR perfusion and T1 mapping. T1 value variations in viable tumour areas and in normal-appearing striated muscle were assessed. In 20 cases, normal muscle perfusion parameters were calculated using three different methods: signal based and gadolinium concentration based on fixed and variable T1 values. Tumour and normal muscle T1 values were significantly different (p = 0.0008). T1 value heterogeneity was higher in tumours than in normal muscle (variation of 19.8% versus 13%). The T1 estimation method had a considerable influence on the variability of perfusion parameters. Fixed T1 values yielded higher coefficients of variation than variable T1 values (mean 109.6 ± 41.8% and 58.3 ± 14.1% respectively). Area under the curve was the least variable parameter (36%). T1 values in musculoskeletal tumours are significantly different and more heterogeneous than normal muscle. Patient-specific T1 estimation is needed for direct inter-patient comparison of perfusion parameters. • T1 value variation in musculoskeletal tumours is considerable. • T1 values in muscle and tumours are significantly different. • Patient-specific T1 estimation is needed for comparison of inter-patient perfusion parameters. • Technical variation is higher in permeability than semiquantitative perfusion parameters.
- Subjects :
- Adult
Male
medicine.medical_specialty
Striated muscle
Value (computer science)
Contrast Media
Soft Tissue Neoplasms
[SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine
Sensitivity and Specificity
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Neoplasms
medicine
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging
Humans
Radiology, Nuclear Medicine and imaging
Musculoskeletal Diseases
Quantitative analysis
Muscle, Skeletal
Neuroradiology
Aged
Musculoskeletal system
Mr perfusion
business.industry
Ultrasound
Area under the curve
Contrast (statistics)
Perfusion magnetic resonance imaging
General Medicine
Middle Aged
Magnetic Resonance Imaging
3. Good health
Perfusion
Female
Radiology
Estimation methods
business
030217 neurology & neurosurgery
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Subjects
Details
- ISSN :
- 14321084 and 09387994
- Volume :
- 27
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- European radiology
- Accession number :
- edsair.doi.dedup.....f5d4807d83ad20d912642ca07d9a6f2f