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Comparison of overall survival on surgical resection versus transarterial chemoembolization with or without radiofrequency ablation in intermediate stage hepatocellular carcinoma: a propensity score matching analysis
- Source :
- BMC Gastroenterology, Vol 20, Iss 1, Pp 1-8 (2020), BMC Gastroenterology
- Publication Year :
- 2020
- Publisher :
- BMC, 2020.
-
Abstract
- Background Patients with Barcelona Clinic Liver Cancer (BCLC) stage B hepatocellular carcinoma (HCC) are recommended to undergo transcatheter arterial chemoembolization (TACE). However, TACE in combination with radiofrequency ablation (RFA) is not inferior to surgical resection (SR), and the benefits of surgical resection (SR) for BCLC stage B HCC remain unclear. Hence, this study aims to compare the impact of SR, TACE+RFA, and TACE on analyzing overall survival (OS) in BCLC stage B HCC. Methods Overall, 428 HCC patients were included in BCLC stage B, and their clinical data and OS were recorded. OS was analyzed by the Kaplan-Meier method and Cox regression analysis. Results One hundred forty (32.7%) patients received SR, 57 (13.3%) received TACE+RFA, and 231 (53.9%) received TACE. The OS was significantly higher in the SR group than that in the TACE+RFA group [hazard ratio (HR): 1.78; 95% confidence incidence (CI): 1.15–2.75, p = 0.009]. The OS was significantly higher in the SR group than that in the TACE group (HR: 3.17; 95% CI: 2.31–4.36, p p = 0.004). The cumulative OS rates at 1, 3 and 5 years in the SR, TACE+RFA, and TACE groups were 89.2, 69.4 and 61.2%, 86.0, 57.9 and 38.2%, and 69.5, 37.0 and 15.2%, respectively. After propensity score matching, the SR group still had a higher OS than those of the TACE+RFA and TACE groups. The TACE+RFA group had a higher OS than that of the TACE group. Conclusion The SR group had higher OS than the TACE+RFA and TACE groups in BCLC stage B HCC. Furthermore, the TACE+RFA group had higher OS than the TACE group.
- Subjects :
- Male
Radiofrequency ablation
Hepatocellular carcinoma
Gastroenterology
law.invention
0302 clinical medicine
law
Overall survival
Stage (cooking)
Aged, 80 and over
Liver Neoplasms
Hazard ratio
General Medicine
Middle Aged
Combined Modality Therapy
Treatment Outcome
030220 oncology & carcinogenesis
Surgical resection
Female
030211 gastroenterology & hepatology
Liver cancer
Research Article
Adult
Barcelona clinic liver Cancer stage B
medicine.medical_specialty
Carcinoma, Hepatocellular
Antineoplastic Agents
03 medical and health sciences
Internal medicine
medicine
Hepatectomy
Humans
Chemoembolization, Therapeutic
lcsh:RC799-869
Propensity Score
Transcatheter arterial chemoembolization
Aged
Retrospective Studies
business.industry
Hepatology
medicine.disease
Survival Analysis
BCLC Stage
Logistic Models
lcsh:Diseases of the digestive system. Gastroenterology
business
Follow-Up Studies
Subjects
Details
- Language :
- English
- Volume :
- 20
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Gastroenterology
- Accession number :
- edsair.doi.dedup.....f5d23bcc00924112ebe84a3924cfaac3