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A polymorphism in the gene encoding carnosinase (CNDP1) as a predictor of mortality and progression from nephropathy to end-stage renal disease in type 1 diabetes mellitus
- Source :
- Diabetologia, 53(12), 2562-2568. SPRINGER, Diabetologia
- Publication Year :
- 2010
- Publisher :
- Springer Science and Business Media LLC, 2010.
-
Abstract
- Aims/hypothesis Homozygosity for a five leucine repeat (5L–5L) in the carnosinase gene (CNDP1) has been found to be cross-sectionally associated with a low frequency of diabetic nephropathy (DN), mainly in type 2 diabetes. We prospectively investigated in patients with type 1 diabetes whether: (1) 5L–5L is associated with mortality; (2) there is an interaction of 5L–5L with DN or sex for prediction of mortality; and (3) 5L–5L is associated with progression to end-stage renal disease (ESRD). Methods In this prospective study in white European patients with type 1 diabetes, individuals with DN were defined by persistent albuminuria ≥300 mg/24 h. Controls without nephropathy were defined by persistent (>15 years) normoalbuminuria
- Subjects :
- Male
Dipeptidases
Endocrinology, Diabetes and Metabolism
Diabetic nephropathy
Type 2 diabetes
Disease
SUSCEPTIBILITY
Gastroenterology
End-stage renal disease
Medicine
Diabetic Nephropathies
AFRICAN-AMERICANS
RISK
COMPLICATIONS
Carnosinase gene
ASSOCIATION
Middle Aged
Prognosis
Type 1 diabetes
CNDP1
Disease Progression
SECRETION
Female
LEUCINE REPEAT
Adult
medicine.medical_specialty
Polymorphism, Single Nucleotide
White People
Article
Nephropathy
End stage renal disease
Internal medicine
Internal Medicine
Humans
Genetic Predisposition to Disease
In patient
Gene
business.industry
medicine.disease
Survival Analysis
TRENDS
Five leucine repeat
Diabetes Mellitus, Type 1
Endocrinology
Case-Control Studies
CELLS
Kidney Failure, Chronic
business
SYSTEM
Follow-Up Studies
Subjects
Details
- ISSN :
- 14320428 and 0012186X
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- Diabetologia
- Accession number :
- edsair.doi.dedup.....f5d06650bd0d371c6812494c1e9f2f90