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Low-Density Lipoprotein-Antioxidant Constituents of Saururus chinensis
- Source :
- Journal of Natural Products. 64:1562-1564
- Publication Year :
- 2001
- Publisher :
- American Chemical Society (ACS), 2001.
-
Abstract
- A new diarylbutane lignan, saururin A (1), and a known 8-O-4'-type neolignan, machilin D (2), were isolated from a total methanol extract of the underground parts of Saururus chinensis. The structures of 1 and 2 were elucidated by spectroscopic data analysis. Compounds 1, 2, and virolin (3) (the methyl ether of 2) exhibited significant low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substance (TBARS) assay with IC(50) values of 8.5, 2.9, and 4.3 microM, respectively.
- Subjects :
- Antioxidant
Spectrophotometry, Infrared
Stereochemistry
medicine.medical_treatment
Pharmaceutical Science
Pharmacognosy
Plant Roots
Thiobarbituric Acid Reactive Substances
Antioxidants
Lignans
Analytical Chemistry
Inhibitory Concentration 50
Magnoliopsida
chemistry.chemical_compound
Drug Discovery
medicine
TBARS
Humans
Phenols
Nuclear Magnetic Resonance, Biomolecular
Pharmacology
Lignan
Saururaceae
Korea
Plants, Medicinal
Chromatography
Molecular Structure
biology
Anti-Inflammatory Agents, Non-Steroidal
Organic Chemistry
Stereoisomerism
biology.organism_classification
Saururus chinensis
Lipoproteins, LDL
Complementary and alternative medicine
chemistry
Low-density lipoprotein
Molecular Medicine
Chromatography, Thin Layer
Subjects
Details
- ISSN :
- 15206025 and 01633864
- Volume :
- 64
- Database :
- OpenAIRE
- Journal :
- Journal of Natural Products
- Accession number :
- edsair.doi.dedup.....f5c3db73449a6e2e9f2d89236261db74