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New azaphilones and tremulane sesquiterpene from endophytic Nigrospora oryzae cocultured with Irpex lacteus
- Source :
- Fitoterapia. 130:26-30
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Five new metabolites belonging to two backbones of pulvilloric acid-type azaphilone and tremulane sesquiterpene were obtained and their structures were determined by spectral analysis. Based on the biogenesis analysis, tremulane sesquiterpenes were obtained from Irpex lacteus by the stimulation of mixed-culture. The antifungal selectivities of metabolites produced by fungus against their co-culture fungus and common pathogens, exhibited competitive interaction of this mix-culture. The tremulane sesquiterpene conocenol B produced by I. lacteus through the induction of Nigrospora oryzae showed selectivity of anti-fungal activity against its co-culture fungus, N. oryzae, with MICs at 16 μg/mL and 128 μg/mL against I. lacteus. The fungus can metabolize these new compounds to inhibit the growth of co-culture fungus while not inhibiting its own growth. Compound 5 was active against acetylcholinesterase (AChE) with a ratio of 35% at the concentration of 50 μM.
- Subjects :
- 0301 basic medicine
Antifungal
medicine.drug_class
Stereochemistry
Irpex lacteus
Fungus
Sesquiterpene
01 natural sciences
03 medical and health sciences
chemistry.chemical_compound
Ascomycota
Drug Discovery
medicine
Benzopyrans
Competitive interaction
Spectral analysis
Nigrospora oryzae
Pharmacology
Molecular Structure
biology
010405 organic chemistry
fungi
Pigments, Biological
General Medicine
biology.organism_classification
Acetylcholinesterase
Coculture Techniques
Fungicides, Industrial
0104 chemical sciences
030104 developmental biology
chemistry
Cholinesterase Inhibitors
Polyporales
Sesquiterpenes
Subjects
Details
- ISSN :
- 0367326X
- Volume :
- 130
- Database :
- OpenAIRE
- Journal :
- Fitoterapia
- Accession number :
- edsair.doi.dedup.....f5be31dc76d5ce22a364f8aa5093636c