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Impairment of T cells' antiviral and anti-inflammation immunities may be critical to death from COVID-19

Authors :
Zhang, Luhao
Li, Rong
Song, Gang
Scholes, Gregory D.
She, Zhen-Su
Source :
Royal Society Open Science, Vol 8, Iss 12 (2021), Royal Society Open Science
Publication Year :
2021
Publisher :
The Royal Society, 2021.

Abstract

Clarifying dominant factors determining the immune heterogeneity from non-survivors to survivors is crucial for developing therapeutics and vaccines against COVID-19. The main difficulty is quantitatively analysing the multi-level clinical data, including viral dynamics, immune response and tissue damages. Here, we adopt a top-down modelling approach to quantify key functional aspects and their dynamical interplay in the battle between the virus and the immune system, yielding an accurate description of real-time clinical data involving hundreds of patients for the first time. The quantification of antiviral responses gives that, compared to antibodies, T cells play a more dominant role in virus clearance, especially for mild patients (96.5%). Moreover, the anti-inflammatory responses, namely the cytokine inhibition and tissue repair rates, also positively correlate with T cell number and are significantly suppressed in non-survivors. Simulations show that the lack of T cells can lead to more significant inflammation, proposing an explanation for the monotonic increase of COVID-19 mortality with age and higher mortality for males. We propose that T cells play a crucial role in the immunity against COVID-19, which provides a new direction–improvement of T cell number for advancing current prevention and treatment.

Details

ISSN :
20545703
Volume :
8
Database :
OpenAIRE
Journal :
Royal Society Open Science
Accession number :
edsair.doi.dedup.....f5baeff41ec6db3b92556e5c4a9c7f2b