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Stereological Estimation of Epidermal Volumes and Dermo-Epidermal Surface Area in Normal Skin
- Source :
- Kamp, S, Balkert, L S, Stenderup, K, Rosada, C, Pakkenberg, B, Kemp, K, Jemec, G & Dam, T N 2011, ' Stereological estimation of epidermal volumes and dermo-epidermal surface area in normal skin ', Dermatology, vol. 223, no. 2, pp. 131-9 . https://doi.org/10.1159/000330737
- Publication Year :
- 2011
- Publisher :
- S. Karger AG, 2011.
-
Abstract
- Quantitative morphological studies of the healthy epidermis are essential in providing a range of parameter estimates that can be considered within the range of normality. Stereology is a set of statistical tools that provides potentially unbiased and precise estimates of 3-dimensional tissue characteristics from 2-dimensional sections. We set out to establish reference values for the volume of the viable epidermis contained within a four-millimetre punch biopsy (Vepi), the volume of the stratum corneum (VSC) and the surface area of the dermo-epidermal junction(ADEJ) in 4 predetermined body regions by use of stereology. Four-millimetre punch biopsies were taken from 20 freshly diseased corpses, fixed in formalin and embedded in paraffin. Vepi, VSC and ADEJ were established stereologically for all 4 body locations followed by pairwise comparison of means after Bonferroni correction. Vepi was significantly larger in the sole compared to all other body locations (p < 0.01). Furthermore, linear regression analysis showed a strong linear relationship between Vepi and VSC in the sole (r = 0.70). Our results suggest that the viable layers of the epidermis might also serve a mechanical function, either directly or by providing the stratum corneum with keratinocytes to support the hyperkeratosis in the weight-bearing parts of the skin.
- Subjects :
- Male
Models, Anatomic
Biopsy
Stereology
Dermatology
Biology
Reference Values
Cadaver
medicine
Humans
Models, Statistical
integumentary system
Foot
Sacrococcygeal Region
fungi
food and beverages
Dermis
Organ Size
Anatomy
Forearm
medicine.anatomical_structure
Reference values
Linear Models
Female
Epidermis
Normal skin
Neck
Subjects
Details
- ISSN :
- 14219832 and 10188665
- Volume :
- 223
- Database :
- OpenAIRE
- Journal :
- Dermatology
- Accession number :
- edsair.doi.dedup.....f5b6c952def168e3adc660c9392ecf73