Back to Search
Start Over
Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development
- Source :
- Genes & Development. 4:683-694
- Publication Year :
- 1990
- Publisher :
- Cold Spring Harbor Laboratory, 1990.
-
Abstract
- We have cloned and characterized the mouse homolog of the human trk proto-oncogene, a member of the protein tyrosine kinase (TK) receptor gene family. Here, we present the first report of a trk-encoded mRNA species in vivo. In situ hybridization analysis in the mouse embryo reveals a striking temporal and spatial regulation of trk transcription, with expression confined to the sensory cranial (trigeminal, superior, jugular) and dorsal root ganglia (DRG) of neural crest origin. Recent reports have shown that TK receptors can play regulatory roles in embryonic development. Thus, the developmental mutations W in mouse and torso and sevenless in Drosophila represent genes that code for defective TK receptors. Our data show that trk, a gene associated with malignancy in humans, is a specific marker for a set of neural crest-derived sensory neurons, and are consistent with the hypothesis that this proto-oncogene may have an important role in the development or phenotype of the neurons where it is expressed.
- Subjects :
- Nervous system
animal structures
Transcription, Genetic
Restriction Mapping
In situ hybridization
Proto-Oncogene Mas
Receptor tyrosine kinase
Mice
Ganglia, Spinal
Sequence Homology, Nucleic Acid
Proto-Oncogenes
Gene expression
Genetics
medicine
Animals
Humans
RNA, Messenger
Cloning, Molecular
Oncogene
biology
Neural crest
Protein-Tyrosine Kinases
Blotting, Northern
Molecular biology
Sensory neuron
Cell biology
Gene Expression Regulation, Neoplastic
medicine.anatomical_structure
Trigeminal Ganglion
nervous system
Neural Crest
Multigene Family
Trk receptor
Mutation
embryonic structures
biology.protein
Ganglia
Developmental Biology
Subjects
Details
- ISSN :
- 15495477 and 08909369
- Volume :
- 4
- Database :
- OpenAIRE
- Journal :
- Genes & Development
- Accession number :
- edsair.doi.dedup.....f57de653f29243073c76eb60ad50e88b