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Consistency of Safety and Efficacy of New Oral Anticoagulants across Subgroups of Patients with Atrial Fibrillation
- Source :
- PLoS ONE, PLoS ONE, 2014, 9 (3), pp.e91398. ⟨10.1371/journal.pone.0091398⟩, PLoS ONE, Vol 9, Iss 3, p e91398 (2014), PLoS ONE, Public Library of Science, 2014, 9, pp.e91398, PLoS One, vol. 9, no. 3, pp. e91398
- Publication Year :
- 2014
- Publisher :
- HAL CCSD, 2014.
-
Abstract
- AIMS: The well-known limitations of vitamin K antagonists (VKA) led to development of new oral anticoagulants (NOAC) in non-valvular atrial fibrillation (NVAF). The aim of this meta-analysis was to determine the consistency of treatment effects of NOAC irrespective of age, comorbidities, or prior VKA exposure. METHODS AND RESULTS: All randomized, controlled phase III trials comparing NOAC to VKA up to October 2012 were eligible provided their results (stroke/systemic embolism (SSE) and major bleeding (MB)) were reported according to age (≤ or >75 years), renal function, CHADS2 score, presence of diabetes mellitus or heart failure, prior VKA use or previous cerebrovascular events. Interactions were considered significant at p
- Subjects :
- medicine.medical_specialty
Clinical Research Design
Epidemiology
Cerebrovascular Diseases
[SDV]Life Sciences [q-bio]
Administration, Oral
lcsh:Medicine
Arrhythmias
Cardiovascular
Cardiovascular Pharmacology
Dabigatran
Internal medicine
Diabetes mellitus
Atrial Fibrillation
Humans
Medicine
lcsh:Science
Stroke
Cardiovascular Disease Epidemiology
Ischemic Stroke
Randomized Controlled Trials as Topic
Heart Failure
Anticoagulants/administration & dosage
Anticoagulants/adverse effects
Atrial Fibrillation/drug therapy
Clinical Trials, Phase III as Topic/methods
Randomized Controlled Trials as Topic/methods
Safety
Rivaroxaban
Multidisciplinary
business.industry
lcsh:R
Warfarin
Anticoagulants
Atrial fibrillation
medicine.disease
3. Good health
Surgery
Neurology
Clinical Trials, Phase III as Topic
Heart failure
Apixaban
lcsh:Q
Meta-Analyses
business
Research Article
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Database :
- OpenAIRE
- Journal :
- PLoS ONE, PLoS ONE, 2014, 9 (3), pp.e91398. ⟨10.1371/journal.pone.0091398⟩, PLoS ONE, Vol 9, Iss 3, p e91398 (2014), PLoS ONE, Public Library of Science, 2014, 9, pp.e91398, PLoS One, vol. 9, no. 3, pp. e91398
- Accession number :
- edsair.doi.dedup.....f578725920334deb3f5e4840ed45f243