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Palladium-Catalyzed Difunctionalization of 1,3-Diene with Amine and Disilane under a Mild Re-oxidation System
- Source :
- Chemistry (Weinheim an der Bergstrasse, Germany). 27(15)
- Publication Year :
- 2021
-
Abstract
- A highly regioselective and stereoselective difunctionalization reaction of 1,3-diene with amine and disilane to form C-N and C-Si bonds via a one-step Pd/Cu/O2 system is disclosed. The difunctionalization reaction affords allylic silanes, including the allylic amine moiety, in up to 92 % yield in the absence of any acid, base, or external ligand. The developed synthetic methodology can be scaled to 100 g in high yield with high Z-selectivity, which demonstrates the feasibility of the reaction for industrial applications.
- Subjects :
- Allylic rearrangement
Diene
010405 organic chemistry
Organic Chemistry
Regioselectivity
chemistry.chemical_element
General Chemistry
010402 general chemistry
01 natural sciences
Catalysis
0104 chemical sciences
chemistry.chemical_compound
chemistry
Yield (chemistry)
Polymer chemistry
Moiety
Amine gas treating
Disilane
Palladium
Subjects
Details
- ISSN :
- 15213765
- Volume :
- 27
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Chemistry (Weinheim an der Bergstrasse, Germany)
- Accession number :
- edsair.doi.dedup.....f57735944086ad84b2906718042138d5