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Hepatitis B (surface) antigen testing by radioimmunoassaymexperience in a very large volunteer donor population
- Source :
- American journal of clinical pathology. 63(6)
- Publication Year :
- 1975
-
Abstract
- The results of hepatitis B surface antigen (HBs-Ag) testing in a large volunteer blood donor population are described. Counterelectrophoresis and three versions of solid-phase radioimmunoassay technic are compared and evaluated. Initial results suggested that the radioimmunoassay technic are compared and evaluated. Initial results suggested that the radioimmunoassay technic detected more than five times as many reactive donors as did counterelectrophoresis. The specificity of the radioimmunoassay technic has been increased by successive modifications, and recent results show that the technic detects 73 percent more reactive donors than does counterelectrophoresis. Not all of these reactions are specific, and it is estimated that the true gain in detection of HBsAg carriers is 49 percent of the value found by counterelectroesis. The incidence of HBsAg carriers in the America Red Cross donor population is about 1.25 per 1,000.
- Subjects :
- Hepatitis
Electrophoresis
education.field_of_study
business.industry
Population
Prevalence
Radioimmunoassay
Blood Donors
General Medicine
Hepatitis B
medicine.disease
Hepatitis b surface antigen
United States
Hepatitis B Antigens
Antigen
Immunology
Carrier State
medicine
Humans
business
education
Counterimmunoelectrophoresis
Subjects
Details
- ISSN :
- 00029173
- Volume :
- 63
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- American journal of clinical pathology
- Accession number :
- edsair.doi.dedup.....f54de336fffd4cd1163b15a0bd7ce63d