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Exhaled breath isoprene rises during hypoglycemia in Type 1 Diabetes
- Source :
- Diabetes Care. 39(7)
- Publication Year :
- 2016
-
Abstract
- Hypoglycemia and/or fear of hypoglycemia are major challenges for many with type 1 diabetes (T1D), limiting ability to lower glycemia. Given anecdotal reports of domestic pets alerting owners to blood glucose changes, especially hypoglycemia (1), we hypothesized that volatile organic compounds (VOCs) in exhaled breath might change at low glucose. We studied eight female nonsmoking participants with T1D (aged 46 ± 5 years, diabetes duration 23 ± 7 years, none treated with statins) twice using a single-blinded, computer code–randomized crossover design. An independent research ethics committee approved studies in advance, and subjects provided written consent. Using a stepped insulin clamp (Actrapid; Novo Nordisk, Crawley, U.K.; 0.3 mU/kg/min increasing to 1.5 mU/kg/min), on one occasion (STEP), arterialized plasma glucose (Yellow Springs Instrument 2300 STAT Plus Analyzer) was raised sequentially (7.1 ± 0.8, 8.7 ± 0.4, and 10.7 ± 0.1 mmol/L) then lowered with higher insulin infusion to 4.3 ± 0.3 and 2.8 ± …
- Subjects :
- 0301 basic medicine
Diabetes duration
medicine.medical_specialty
endocrine system diseases
Endocrinology, Diabetes and Metabolism
030209 endocrinology & metabolism
Hypoglycemia
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Internal medicine
Internal Medicine
medicine
skin and connective tissue diseases
Independent research
Advanced and Specialized Nursing
Type 1 diabetes
business.industry
Ethics committee
nutritional and metabolic diseases
medicine.disease
Insulin clamp
Crossover study
030104 developmental biology
Endocrinology
sense organs
business
Subjects
Details
- Language :
- English
- ISSN :
- 19355548 and 01495992
- Volume :
- 39
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Diabetes Care
- Accession number :
- edsair.doi.dedup.....f5354ad115ad1688c5f01c3980f21376