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Effect of sirolimus on renal ischaemia/reperfusion injury in normotensive and hypertensive rats
- Source :
- Transplant International. 17:432-441
- Publication Year :
- 2004
- Publisher :
- Frontiers Media SA, 2004.
-
Abstract
- Background. Renal ischaemia/reperfusion (I/R) injury and hypertension represent major alloantigen-independent factors contributing to the development of chronic allograft nephropathy of renal allografts. In the present study, we investigated the effect of the anti-proliferative immunosuppressant, sirolimus (SIR), in a model of accelerated renal injury in hypertensive transgenic rats (TGRs). Twenty anaesthetized uninephrectomized TGRs with renin overproduction [TGR(mREN2)27] and 20 normotensive Han SD (SD) rats as genetic controls had their renal pedicles clipped for 45 min and were subsequently treated with either SIR (0.5 mg/kg per day, orally) or placebo (n=10 in each group) for 16 weeks, after which time the kidneys were harvested for morphological and immunohistochemical analysis. High-renin hypertension aggravated the functional and structural changes induced by I/R in SD animals: both SIR-treated and untreated TGRs exhibited significantly greater proteinuria and suffered from more severe glomerulosclerosis (P
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Renal function
Blood Pressure
Kidney Function Tests
Renal Circulation
Animals, Genetically Modified
Rats, Sprague-Dawley
Mice
Chronic allograft nephropathy
Rats, Inbred SHR
Internal medicine
Renin
medicine
Animals
Urea
Antibacterial agent
Sirolimus
Transplantation
Kidney
Proteinuria
business.industry
Glomerulosclerosis
medicine.disease
Rats
Endocrinology
medicine.anatomical_structure
Creatinine
Reperfusion Injury
medicine.symptom
business
Immunosuppressive Agents
Kidney disease
Subjects
Details
- ISSN :
- 14322277 and 09340874
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Transplant International
- Accession number :
- edsair.doi.dedup.....f5347ffb25bae78f1f68980b7d3357d2