THE ANTHELMİNTİc EFFECT OF BROTİANİDE* AGAİNST FAScİoLA GİGANTİCA İNFECTİoNS İN SHEEP

4 % solution of Brotianide was found 68-97 % effective when given at2-4 mL.JIO kg. orally to sheep carrying 40 dayold Fasciola gigantica infections.it was alsa found to be 90 and 99 % efficient at the dose level of 1.2-2.5 mL./ iO kg. insixty dayold infeetions and 97 and 100 % whcn adminİstered 1.2-2 mL./ iO kg. in 90 day infections.Ko side effect of the drug was secn in any sheep treated within the dose ranges used.Fasciola gigantica infections still are a severe problem particularly in the southcm,and Marmara sea arcas of the wcstcrn parts afTurkey. According to the reports ofmeat inspectors and field veterinarians of those areas, the spread of the infection has reached critica!proportions.At present, drugs containing hexachlorophene, oxyelozanide, menichlopholan and inrestricted areas hcxachloroethane are in use in this country against the giant nuke.The present paper reports the activity of Brotianide (2-acetoxy-3-brom-5-chlor-N-(4'-bromphenyl)- thionobenzamid) against diffcrent development stages of Fasciola gigantica insheep.According to Roseby and Boray (I) the minimum dose rates of Brotianide that gaye90 % or higher efficieney against 6 weeks and 12 weeks old Fasciola hepatica infeetions, werı:4.7 mg./kg. and 2.3 mg./kg. respectively and maximum tolerated dose rate was 27 mg./kg.in artificially infeeted sheep.