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Nutrient dietary patterns and gastric cancer risk in Italy
- Source :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(11)
- Publication Year :
- 2009
-
Abstract
- Background: There have been several studies on diet and gastric cancer, but only a few investigations have considered the role of dietary patterns. Methods: We investigated gastric cancer risk in relation to dietary patterns in a case-control study conducted in northern Italy between 1997 and 2007, including 230 patients with incident, histologically confirmed gastric cancer and 547 frequency-matched controls, admitted to the same hospitals as cases, with acute nonneoplastic conditions. Dietary habits were investigated through a validated food frequency questionnaire including 78 foods and beverages. We identified a posteriori dietary patterns on a selected set of 28 micro- and macro-nutrients through an exploratory principal component factor analysis. We estimated the odds ratios (OR) and the corresponding 95% confidence intervals (95% CI) using conditional logistic regression models on quartiles of factor scores. Results: We identified four major dietary patterns, named “animal products”, “vitamins and fiber”, “vegetable unsaturated fatty acids”, and “starch-rich”. We observed a positive association between gastric cancer risk and the “animal products” (OR, 2.13; 95% CI, 1.34-3.40, for the highest versus the lowest score quartile) and the “starch-rich” (OR, 1.67; 95% CI, 1.01-2.77) dietary patterns. The “vitamins and fiber” pattern (OR, 0.60; 95% CI, 0.37-0.99) was inversely associated with gastric cancer, whereas no significant association emerged with the “vegetable unsaturated fatty acids” pattern (OR, 0.89; 95% CI, 0.56-1.42). Conclusions: Our analysis suggests a protective effect against gastric cancer risk of dietary patterns rich in fruits and vegetables, and a positive association of dietary patterns rich in meats and animal fats and starchy foods. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2882–6)
- Subjects :
- Adult
Male
medicine.medical_specialty
Epidemiology
Gastroenterology
Risk Assessment
Young Adult
Stomach Neoplasms
Internal medicine
Vegetables
medicine
Humans
Risk factor
Stomach cancer
Aged
Aged, 80 and over
business.industry
Stomach
Case-control study
Cancer
Starch
Odds ratio
Feeding Behavior
Middle Aged
medicine.disease
Prognosis
Dietary Fats
Diet
medicine.anatomical_structure
Oncology
Quartile
Italy
Case-Control Studies
Fruit
Female
Risk assessment
business
Subjects
Details
- ISSN :
- 15387755
- Volume :
- 18
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Accession number :
- edsair.doi.dedup.....f50cd378e95e924cc08ba85f2a7796ba