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Follow-up of children born after ICSI with epididymal spermatozoa
- Source :
- Human Reproduction, 26, 1759-67, Human Reproduction, 26, 7, pp. 1759-67
- Publication Year :
- 2011
- Publisher :
- Oxford University Press (OUP), 2011.
-
Abstract
- Contains fulltext : 97926.pdf (Publisher’s version ) (Closed access) BACKGROUND: To evaluate the safety of ICSI with epididymal sperm, this study compared children born after ICSI treatment with epididymal sperm and children conceived after IVF and ICSI with ejaculated sperm. Additionally, the results of a multidisciplinary, multicentre follow-up of the children conceived with epididymal sperm at 2 years of age are described. METHODS: This follow-up study included 378 children conceived after ICSI with epididymal sperm (percutaneous epididymal sperm aspiration: PESA group) and a control group of 1192 IVF and 1126 ICSI (with ejaculated sperm) children, all with a gestational age of 20 weeks or more. Questionnaires were sent at birth, 1 year and 4 years of age, collecting data on parental, pregnancy and child factors. A total of 148 PESA children were assessed at 2 years of age for motor performance, mental- and language development and compared with the Dutch norms. RESULTS: PESA children showed no increased risks for stillbirths, total deaths and malformations. They also did not differ from IVF and ICSI children in gender rate, birthweight and gestational age. The mental Bayley score was higher (P < 0.05) for PESA singletons and parents reported fewer (P < 0.05) behavioural problems in the PESA group than the Dutch reference group. The scores for syntactic and lexical development for the PESA singletons were better (P < 0.05) than the Dutch standards. CONCLUSIONS: ICSI with epididymal sperm does not lead to more stillbirths or congenital malformations in comparison to IVF and ICSI with ejaculated sperm and does not lead to poor development in comparison with the Dutch reference group.
- Subjects :
- Male
medicine.medical_specialty
Sperm Retrieval
Birth weight
Quality of nursing and allied health care [NCEBP 6]
Twins
Epididymal sperm
Fertilization in Vitro
Risk Assessment
Congenital Abnormalities
Sperm cell
Pregnancy
Humans
Medicine
Prospective Studies
Sperm Injections, Intracytoplasmic
Child
reproductive and urinary physiology
Epididymis
Gynecology
urogenital system
business.industry
Obstetrics
Hormonal regulation [IGMD 6]
Rehabilitation
Pregnancy Outcome
Obstetrics and Gynecology
Gestational age
Congenital malformations
Functional imaging [IGMD 1]
medicine.disease
Spermatozoa
Human Reproduction [NCEBP 12]
Reproductive Medicine
Ejaculated sperm
embryonic structures
Female
Quality of hospital and integrated care [NCEBP 4]
business
therapeutics
Percutaneous epididymal sperm aspiration
Follow-Up Studies
Subjects
Details
- ISSN :
- 14602350 and 02681161
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Human Reproduction
- Accession number :
- edsair.doi.dedup.....f50bbeab8ce6a026974613330e115e27