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Comprehensive network map of transcriptional activation of chicken type I IFNs and IFN-stimulated genes
- Source :
- Comparative immunology, microbiology and infectious diseases. 68
- Publication Year :
- 2019
-
Abstract
- Chicken type I interferons (type I IFNs) are key antiviral players of the chicken immune system and mediate the first line of defense against viral pathogens infecting the avian species. Recognition of viral pathogens by specific pattern recognition receptors (PRRs) induce chicken type I IFNs expression followed by their subsequent interaction to IFN receptors and induction of a variety of IFN stimulated antiviral proteins. These antiviral effectors establish the antiviral state in neighboring cells and thus protect the host from infection. Three subtypes of chicken type I IFNs; chIFN-α, chIFN-β, and a recently discovered chIFN-κ have been identified and characterized in chicken. Chicken type I IFNs are activated by various host cell pathways and constitute a major antiviral innate defense in chicken. This review will help to understand the chicken type 1 IFNs, host cellular pathways that are involved in activation of chicken type I IFNs and IFN stimulated antiviral effectors along with the gaps in knowledge which will be important for future investigation. These findings will help us to comprehend the role of chicken type I IFNs and to develop different strategies for controlling viral infection in poultry.
- Subjects :
- Transcriptional Activation
animal structures
040301 veterinary sciences
First line
030231 tropical medicine
Immunology
Biology
Microbiology
Viral infection
0403 veterinary science
03 medical and health sciences
0302 clinical medicine
Immune system
Immunology and Allergy
Animals
Gene Regulatory Networks
Receptor
Gene
General Veterinary
Host Microbial Interactions
Effector
Cellular pathways
Pattern recognition receptor
04 agricultural and veterinary sciences
General Medicine
Virology
Infectious Diseases
Virus Diseases
embryonic structures
Interferon Type I
Chickens
Subjects
Details
- ISSN :
- 18781667
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Comparative immunology, microbiology and infectious diseases
- Accession number :
- edsair.doi.dedup.....f50ab6d53fda485ddbdc0eeccb5debcb