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Maternal history of type 2 diabetes is associated with diabetic nephropathy in type 1 diabetic patients
- Source :
- Diabetes and Metabolism, Diabetes and Metabolism, Elsevier Masson, 2007, 33 (1), pp.37-43. ⟨10.1016/j.diabet.2006.09.003⟩
- Publication Year :
- 2006
-
Abstract
- International audience; AIMS: Insulin resistance is a key feature of type 2 diabetes. It is also involved in the development and progression of microvascular complications. We analysed the relationship between parental history of diabetes, insulin resistance and diabetic nephropathy (DN) and assessed the specific maternal and paternal influences of history of type 2 diabetes on DN in type 1 diabetic offspring. METHODS: We recorded information regarding family history of type 2 diabetes and of cardiovascular disease in 160 consecutive, unrelated type 1 diabetic patients. Insulin resistance was assessed using a validated estimation of the glucose disposal rate (eGDR). RESULTS: Type 1 diabetic patients with a maternal history of type 2 diabetes were more likely to be insulin-resistant (P=0.043) and to have renal complications (P=0.0041) than those from the reference group (without parental history of diabetes), while patients with a paternal history were not different from those from the reference group, regarding eGDR and DN. Time to development of abnormal albuminuria was significantly affected by maternal history of type 2 diabetes (log-rank=12.66; P=0.0004) and by familial history of premature cardiovascular disease (log-rank=5.48; P=0.0234). In multivariate analysis, a maternal history of type 2 diabetes was independently associated with nephropathy after adjustment for sex, diabetes duration and familial history of premature cardiovascular disease. CONCLUSION: Maternal history of type 2 diabetes is independently associated with DN in type 1 diabetic patients. This might suggest the transmission of a maternal trait related to microvascular complications, raising the hypothesis of imprinted genes predisposing to diabetic renal disease.
- Subjects :
- Male
Endocrinology, Diabetes and Metabolism
Blood Pressure
Type 2 diabetes
Body Mass Index
Diabetic nephropathy
0302 clinical medicine
Endocrinology
MESH: Cholesterol
Body Size
Diabetic Nephropathies
030212 general & internal medicine
Family history
Medical History Taking
2. Zero hunger
General Medicine
MESH: Blood Pressure
Lipids
MESH: Mothers
3. Good health
MESH: Insulin Resistance
Cholesterol
MESH: Hemoglobin A, Glycosylated
[SDV.IMM]Life Sciences [q-bio]/Immunology
Female
France
medicine.symptom
MESH: Diabetes Mellitus, Type 1
MESH: Diabetes Mellitus, Type 2
medicine.medical_specialty
MESH: Diabetic Nephropathies
Mothers
030209 endocrinology & metabolism
Nephropathy
MESH: Body Mass Index
03 medical and health sciences
Insulin resistance
Internal medicine
Diabetes mellitus
Internal Medicine
medicine
Humans
Glycated Hemoglobin
Type 1 diabetes
MESH: Humans
MESH: Body Size
business.industry
MESH: Medical History Taking
medicine.disease
MESH: Lipids
MESH: Male
MESH: France
Diabetes Mellitus, Type 1
Diabetes Mellitus, Type 2
Albuminuria
Insulin Resistance
business
MESH: Female
Subjects
Details
- ISSN :
- 12623636
- Volume :
- 33
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Diabetesmetabolism
- Accession number :
- edsair.doi.dedup.....f4ffdec186a38d178f83ee475873de7b