Back to Search
Start Over
A Review on Dapsone Hypersensitivity Syndrome Among Chinese Patients with an Emphasis on Preventing Adverse Drug Reactions with Genetic Testing
- Source :
- The American Journal of Tropical Medicine and Hygiene
- Publication Year :
- 2017
- Publisher :
- The American Society of Tropical Medicine and Hygiene, 2017.
-
Abstract
- Dapsone is a bactericidal and bacteriostatic against Mycobacterium leprae, a causative agent of leprosy. Dapsone is also applied in a range of medical fields because of its anti-inflammatory and immunomodulatory effects. Dapsone hypersensitivity syndrome (DHS) is a rare yet serious adverse drug reaction (ADR) caused by dapsone involving multiple organs. We performed a systematic review of published articles describing dapsone-induced hypersensitivity syndrome, including all Chinese articles and the latest literature available in online databases published between October 2009 and October 2015. We determined the prevalence, clinical characteristics, and mortality rate of DHS. Importantly, we also summarized the recent advances in genetic testing allowing prediction of ADRs. In an initial systematic electronic search, we retrieved 191 articles. Subsequently, these articles were further filtered and ultimately 84 articles (60 Chinese case reports, 21 non-Chinese articles, and three epidemiological studies) were selected, which included 877 patients. The prevalence of DHS among Chinese patients was 1.5% with a fatality rate of 9.6%. Early withdrawal of dapsone and appropriate treatment reduced the fatality rate. Most importantly, genetic screening for the HLA-B*13:01 allele among high-risk populations showed a significant utility as a useful genetic marker to DHS. In conclusion, this review discusses the epidemiological and clinical characteristics of DHS among Chinese patients, which may help physicians to understand this syndrome.
- Subjects :
- 0301 basic medicine
Adult
Male
medicine.medical_specialty
China
Adolescent
Leprostatic Agents
Pharmacology
Dapsone
Drug Hypersensitivity
03 medical and health sciences
Pharmacotherapy
Virology
Internal medicine
Leprosy
Case fatality rate
medicine
Prevalence
Humans
Genetic Testing
Adverse effect
Child
Review Articles
Alleles
HLA-B13 Antigen
Genetic testing
Aged
medicine.diagnostic_test
business.industry
Drug Substitution
Mortality rate
Syndrome
Middle Aged
medicine.disease
Survival Analysis
Mycobacterium leprae
Primary Prevention
030104 developmental biology
Infectious Diseases
Parasitology
Female
business
Adverse drug reaction
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14761645 and 00029637
- Volume :
- 96
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- The American Journal of Tropical Medicine and Hygiene
- Accession number :
- edsair.doi.dedup.....f4e276326a7da46b192d2c8a0c5a46e2