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Vitamin D, gut microbiota, and radiation-related resistance: a love-hate triangle
- Source :
- Journal of Experimental & Clinical Cancer Research, Vol 38, Iss 1, Pp 1-10 (2019), Journal of Experimental & Clinical Cancer Research : CR
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Radiation resistance is a serious issue in radiotherapy. Increasing evidence indicates that the human gut microbiome plays a role in the development of radiation resistance. Vitamin D is an important supplement for cancer patients treated with radiotherapy. Against this background, this paper reviewed research regarding the associations among vitamin D, microbiota dysbiosis, and radiation resistance. A hypothesis is developed to describe the relationships among vitamin D, the gut microbiota, and radiotherapy outcomes. Radiotherapy changes the composition of the gut microbiota, which in turn influence the serum level of vitamin D, and its distribution and metabolism in the body. Alteration of vitamin D level influences the patient response to radiotherapy, where the underlying mechanisms may be associated with the intestinal microenvironment, immune molecules in the intestines, gut microbiome metabolites, and signaling pathways associated with vitamin D receptors. Our understanding of the contribution of vitamin D and the gut microbiota to radiotherapy outcomes has been increasing gradually. A better understanding of the relationships among vitamin D, the gut microbiota, and radiotherapy outcomes will shed more light on radiation resistance, and also promote the development of new strategies for overcoming it, thus addressing an important challenge associated with the currently available radiotherapy modalities for cancer patients.
- Subjects :
- 0301 basic medicine
Cancer Research
Radiation resistance
medicine.medical_treatment
Review
Gut microbiota
Gut flora
Patient response
Bioinformatics
Radiation Tolerance
lcsh:RC254-282
digestive system
03 medical and health sciences
0302 clinical medicine
Immune system
Neoplasms
Vitamin D and neurology
medicine
Humans
Microbiome
Vitamin D
biology
business.industry
Cancer
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
biology.organism_classification
medicine.disease
Gastrointestinal Microbiome
Radiation therapy
030104 developmental biology
Oncology
030220 oncology & carcinogenesis
Receptors, Calcitriol
business
Dysbiosis
Signal Transduction
Subjects
Details
- ISSN :
- 17569966
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- Journal of Experimental & Clinical Cancer Research
- Accession number :
- edsair.doi.dedup.....f4d6a2a3cea2f5e2cd99a830e0e7d647