Back to Search
Start Over
Structure-function studies of DNA polymerase lambda
- Source :
- DNA repair. 4(12)
- Publication Year :
- 2005
-
Abstract
- DNA polymerase lambda is a member of the X family of polymerases that is implicated in non-homologous end-joining of double-strand breaks in DNA and in base excision repair of DNA damage. To better understand the roles of DNA polymerase lambda in these repair pathways, here we review its structure and biochemical properties, with emphasis on its gap-filling polymerization activity, its dRP lyase activity and its unusual DNA synthetic (in)fidelity.
- Subjects :
- DNA clamp
biology
DNA polymerase
DNA polymerase II
Cell Biology
Biochemistry
DNA polymerase delta
Molecular biology
DNA polymerase lambda
Protein Structure, Tertiary
Structure-Activity Relationship
biology.protein
Humans
Nucleic Acid Conformation
Phosphorus-Oxygen Lyases
Molecular Biology
DNA polymerase mu
Polymerase
DNA Polymerase beta
Nucleotide excision repair
Subjects
Details
- ISSN :
- 15687864
- Volume :
- 4
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- DNA repair
- Accession number :
- edsair.doi.dedup.....f4d2aac2282fd7e4d04778f7d6092592