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Extraction, structure, pharmacological activities and drug carrier applications of Angelica sinensis polysaccharide
- Source :
- International Journal of Biological Macromolecules. 183:2337-2353
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Angelica sinensis polysaccharide (ASP) is one of the main active components of Angelica sinensis (AS) that is widely used in traditional Chinese medicine. ASP is water-soluble polysaccharides, and it is mainly composed of glucose (Glc), galactose (Gal), arabinose (Ara), rhamnose (Rha), fucose (Fuc), xylose (Xyl) and galacturonic acid (GalUA). The extraction methods of ASP include hot water extraction and ultrasonic wave extraction, and different extraction methods can affect the yield of ASP. ASP has a variety of pharmacological activities, including hematopoietic activity, promoting immunity, antitumor, anti-inflammatory, antioxidant, anti-aging, anti-virus, liver protection, and so on. As a kind of natural polysaccharide, ASP has potential application as drug carriers. This review provides a comprehensive summary of the latest extraction and purification methods of ASP, the strategies used for monosaccharide compositional analysis plus polysaccharide structural characterization, pharmacological activities and drug carrier applications, and it can provide a basis for further study on ASP.
- Subjects :
- Arabinose
Angelica sinensis
Rhamnose
02 engineering and technology
Polysaccharide
Biochemistry
Fucose
Structure-Activity Relationship
03 medical and health sciences
chemistry.chemical_compound
Polysaccharides
Structural Biology
Animals
Humans
Monosaccharide
Molecular Biology
030304 developmental biology
chemistry.chemical_classification
Drug Carriers
0303 health sciences
Molecular Structure
biology
Plant Extracts
General Medicine
021001 nanoscience & nanotechnology
biology.organism_classification
Hot water extraction
chemistry
Galactose
0210 nano-technology
Subjects
Details
- ISSN :
- 01418130
- Volume :
- 183
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....f4cd479516e9b56c3e26491cbe71a083