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Induction of Gut Microbial Tryptamine by SARS-CoV-2 in Nonhuman Primate Model Consistent with Tryptamine-Induced Model of Neurodegeneration
- Source :
- Journal of Alzheimer's Disease Reports
- Publication Year :
- 2021
- Publisher :
- IOS Press, 2021.
-
Abstract
- The author discussed recently the possible molecular mechanisms that cause the COVID-19 disease symptoms. Here the analysis of the recent experimental data supports the hypothesis that production of the gut microbial tryptamine can be induced by the SARS-CoV-2 fecal viral activity due to the selective pressure or positive selection of tryptamine-producing microorganisms. In this report, the author suggests that the mechanism of microbial selection bases on the abilities of tryptamine to affect the viral nucleic acid. In other words, the gut microorganisms producing tryptamine are more resistant to SARS-CoV-2 fecal viral activity than microorganisms producing no tryptamine. Earlier we demonstrated the induction of neurodegeneration by tryptamine in human cells and mouse brain. Furthermore, we were able to uncover the human gut bacteria associated with Alzheimer’s disease (AD) using PCR testing of human fecal samples with the new-designed primers targeting the tryptophan-tryptamine pathway. Likely, SARS-CoV-2 is one of the selective pressure factors in the cascade accelerating the neurodegenerative process in AD. This suggestion is consistent with a higher proportion of AD patients among COVID-19 related victims. Gut microbial tryptamine increase due to the viral infection-induced dysbiosis can synergize and potentiate the tryptamine cytotoxicity, necrotizing ability and other properties as a virulence factor.
- Subjects :
- Tryptamine
necrotizing ability
Virulence factor
Microbiology
chemistry.chemical_compound
medicine
Cytotoxicity
Feces
tryptophanyl-tRNA synthetase
biology
SARS-CoV-2
Mechanism (biology)
General Neuroscience
Neurodegeneration
COVID-19
PCR testing
dysbiosis
Hypothesis
biology.organism_classification
medicine.disease
Psychiatry and Mental health
Clinical Psychology
chemistry
human gut microbiome biogenic amines
tryptamine-induced model of neurodegeneration
Geriatrics and Gerontology
Alzheimer’s disease
Dysbiosis
Bacteria
Subjects
Details
- ISSN :
- 25424823
- Volume :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of Alzheimer's Disease Reports
- Accession number :
- edsair.doi.dedup.....f4b1b3fb6bbc84675d59b8afd6b10388
- Full Text :
- https://doi.org/10.3233/adr-210032