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HER2 status in gastric and gastroesophageal junction cancer assessed by local and central laboratories: Chinese results of the HER-EAGLE study
- Source :
- PLoS ONE, PLoS ONE, Vol 8, Iss 11, p e80290 (2013)
- Publication Year :
- 2013
-
Abstract
- Trastuzumab has been approved for human epidermal growth factor receptor 2 (HER2)-positive advanced gastric and gastroesophageal junction cancers (GC and GJC) in combination with chemotherapy. The aim of this HER2 early/advanced gastric epidemiology (HER-EAGLE) study was to evaluate the frequency of HER2 over-expression and to evaluate agreement on HER2 status assessment in GC and GJC patients in local laboratories versus a central laboratory in China. Tumor samples from 734 GC or GJC patients who were enrolled at 11 different hospitals in China were examined. HER2 status was assessed by immunohistochemistry (IHC), and followed by dual-color silver-enhanced in Situ hybridization (DSISH) in IHC 2+ cases. Clinicopathologic characteristics were collected from all of the patients. HER2-positive tumors were identified in 12.0% (88/734) of the GC and GJC cases. There were significantly higher rates of HER2 positivity in patients with GJC (GJC: 18.1%, GC: 9.7%, P=0.002), and intestinal-type cancers using the Lauren classification (intestinal: 23.6%, diffuse/mixed: 4.3%, P
- Subjects :
- Male
medicine.medical_specialty
Pathology
Receptor, ErbB-2
medicine.medical_treatment
lcsh:Medicine
Gastroesophageal Junction
Gastroenterology
Trastuzumab
Stomach Neoplasms
Internal medicine
Epidemiology
Biopsy
medicine
Biomarkers, Tumor
Humans
lcsh:Science
skin and connective tissue diseases
In Situ Hybridization
Chemotherapy
Multidisciplinary
medicine.diagnostic_test
business.industry
lcsh:R
Cancer
Middle Aged
medicine.disease
Immunohistochemistry
lcsh:Q
Female
Esophagogastric Junction
business
Kappa
medicine.drug
Research Article
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 8
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....f4ad6bbdf1eb0496493557173ba25283