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Multimodal imaging analyses of hyperreflective dot-like lesions in acute syphilitic posterior placoid chorioretinopathy
- Source :
- Journal of Ophthalmic Inflammation and Infection, Repositório Institucional da UNIFESP, Universidade Federal de São Paulo (UNIFESP), instacron:UNIFESP
- Publication Year :
- 2016
-
Abstract
- Background: Retrospective review of one acute syphilitic posterior placoid chorioretinitis (ASPPC) case with serological evidence of syphilis who had ocular signs and symptoms not attributable to other diseases. Enface and spectral-domain optical coherence tomographySD-OCT were analyzed at the time of presentation and at 1-month visit following initiation of treatment. The study patient underwent standard treatment for neurosyphilis. Results: Ophthalmic examination and imaging studies were consistent with the diagnosis of ASPPC. The patient age was 33 year-old and the baseline visual acuity was 20/400 and 20/80 in the right and left eyes, respectively. At presentation, SD-OCT scans showed disruption and loss of the ellipsoid zone (EZ), small nodular elevations on retinal pigment epithelium (RPE) and punctate hyperreflectivity in the choroid. Enface OCT at the level of RPE and EZ demonstrated multiple hyperreflective dot-like lesions simmetrically distributed within the macular area. These dot-like lesions corresponded to the small nodular elevations on RPE and to disruption/loss of EZ observed with SD-OCT. One month after neurosyphilis therapy, the visual acuity improved and the outer retinal changes partially reversed in both eyes. Conclusions: We report the outer retinal findings and its correlation using both en-face and SD-OCT in a patient with ASPPC. En-face OCT imaging provides a more precise outer retinal layers analyses allowing a better understanding of the ASPPC pathophysiology. Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil Fed Univ Sao Paulo UNIFESP, Rua Botucatu,821,Vila Clementino, BR-04023062 Sao Paulo, SP, Brazil Univ Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil Fed Univ Sao Paulo UNIFESP, Rua Botucatu,821,Vila Clementino, BR-04023062 Sao Paulo, SP, Brazil Web of Science
- Subjects :
- En-face optical coherence tomography
Pathology
medicine.medical_specialty
Visual acuity
genetic structures
Neurosyphilis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Outer retinal abnormalities
Medicine
Spectral-domain optical coherence tomography
030212 general & internal medicine
Syphilis
Retinal pigment epithelium
business.industry
Standard treatment
Brief Report
Chorioretinitis
Retinal
medicine.disease
eye diseases
Ophthalmology
Infectious Diseases
medicine.anatomical_structure
chemistry
Acute syphilitic posterior placoid chorioretinitis
030221 ophthalmology & optometry
Choroid
sense organs
medicine.symptom
business
Subjects
Details
- ISSN :
- 18695760
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of ophthalmic inflammation and infection
- Accession number :
- edsair.doi.dedup.....f4ac09017f325167ef897561c1cf3ddc