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Exercise and Prognosis on the Basis of Clinicopathologic and Molecular Features in Early-Stage Breast Cancer: The LACE and Pathways Studies
- Source :
- Cancer Research. 76:5415-5422
- Publication Year :
- 2016
- Publisher :
- American Association for Cancer Research (AACR), 2016.
-
Abstract
- To investigate whether the impact of postdiagnosis exercise on breast cancer outcomes in women diagnosed with early-stage breast cancer differs on the basis of tumor clinicopathologic and molecular features. Using a prospective design, 6,211 patients with early-stage breast cancer from two large population-based cohort studies were studied. Age-adjusted and multivariable Cox regression models were performed to determine the relationship between exercise exposure (total MET-hours/week) and recurrence and breast cancer–related death for: (i) all patients (“unselected” cohort), and on the basis of (ii) classic clinicopathologic features, (iii) clinical subtypes, (iv) PAM50-based molecular intrinsic subtypes, and (v) individual PAM50 target genes. After a median follow-up of 7.2 years, in the unselected cohort (n = 6,211) increasing exercise exposure was not associated with a reduction in the risk of recurrence (adjusted Ptrend = 0.60) or breast cancer–related death (adjusted Ptrend = 0.39). On the basis of clinicopathologic features, an exercise-associated reduction in breast cancer–related death was apparent for tumors
- Subjects :
- Adult
0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Breast Neoplasms
Article
Cohort Studies
03 medical and health sciences
0302 clinical medicine
Breast cancer
Internal medicine
Humans
Medicine
Stage (cooking)
Exercise physiology
Exercise
Aged
Proportional Hazards Models
Gynecology
business.industry
Proportional hazards model
Cancer
Middle Aged
Prognosis
medicine.disease
Confidence interval
030104 developmental biology
030220 oncology & carcinogenesis
Cohort
Female
Neoplasm Recurrence, Local
business
Cohort study
Subjects
Details
- ISSN :
- 15387445 and 00085472
- Volume :
- 76
- Database :
- OpenAIRE
- Journal :
- Cancer Research
- Accession number :
- edsair.doi.dedup.....f4aac505dee9ca5ba9f87f81bf8b067c