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Treatment outcomes of pachychoroid neovasculopathy with photodynamic therapy and anti-vascular endothelial growth factor
- Source :
- Indian Journal of Ophthalmology, Vol 67, Iss 10, Pp 1678-1683 (2019), Indian Journal of Ophthalmology
- Publication Year :
- 2019
- Publisher :
- Wolters Kluwer Medknow Publications, 2019.
-
Abstract
- Purpose: To describe treatment outcomes of eyes with pachychoroid neovasculopathy (PNV) with PDT and anti-(vascular endothelial growth factor) VEGF therapy. Methods: Retrospective interventional case series. Records of six consecutive cases of PNV were reviewed. Four cases were treated with PDT+ inj ranibizumab. Two cases underwent only PDT. Final visual outcomes and functional outcome including macular status and choroidal thickness were assessed. Results: We analysed six eyes of six patients with PNV. There were four males and two females. Mean age of the patients was 56.5 years. Mean duration of follow up was 8.2 months. All patients received reduced fluence PDT. Four patients received ranibizumab along with PDT; mean BCVA at presentation was 0.41 log MAR units and mean BCVA at final follow up was 0.44 log MAR units. There was significant improvement at final follow up (P = 0.03). Mean subfoveal choroidal thickness (SFCT) at presentation was 445 microns and mean SFCT at final follow up was 293 microns. There was a significant reduction at final follow up (P = 0.02). Conclusion: PDT with or without ranibizumab appears to be an effective treatment modality for PNV.
- Subjects :
- Vascular Endothelial Growth Factor A
genetic structures
VEGF receptors
medicine.medical_treatment
Treatment outcome
Visual Acuity
Photodynamic therapy
Angiogenesis Inhibitors
chemistry.chemical_compound
0302 clinical medicine
lcsh:Ophthalmology
Fluorescein Angiography
Anti vegf
Photosensitizing Agents
pachychoroid neovasculopathy
biology
Middle Aged
Vascular endothelial growth factor
Treatment Outcome
Intravitreal Injections
Drug Therapy, Combination
Original Article
Tomography, Optical Coherence
medicine.drug
medicine.medical_specialty
Fundus Oculi
03 medical and health sciences
Ophthalmology
Ranibizumab
medicine
Effective treatment
Humans
Aged
Retrospective Studies
business.industry
Choroid
pachychoroid disease
Mean age
Choroidal Neovascularization
eye diseases
chemistry
Photochemotherapy
OCT
lcsh:RE1-994
030221 ophthalmology & optometry
biology.protein
business
030217 neurology & neurosurgery
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 19983689 and 03014738
- Volume :
- 67
- Issue :
- 10
- Database :
- OpenAIRE
- Journal :
- Indian Journal of Ophthalmology
- Accession number :
- edsair.doi.dedup.....f4a7a53622901c215b6aa570f18b346d