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Concentrations of Selected Adipokines, Interleukin-6, and Vitamin D in Patients with Papillary Thyroid Carcinoma in Respect to Thyroid Cancer Stages
- Source :
- International Journal of Endocrinology, Vol 2018 (2018), International Journal of Endocrinology
- Publication Year :
- 2018
- Publisher :
- Hindawi Limited, 2018.
-
Abstract
- The relationships between thyroid cancer and obesity are not fully understood. Adipokines, proinflammatory cytokines, and vitamin D may mediate these associations. In this study, we estimated serum concentrations of leptin, adiponectin, chemerin, interleukin-6 (IL-6), and vitamin D in patients with papillary thyroid cancer (PTC). We searched for associations between the adipokines, IL-6, vitamin D, anthropometric parameters, and TNM AJCC/UICC 2017 classification in 177 patients diagnosed with PTC (151 women and 26 men). Normal weight patients were predominantly classified as clinical stage I. The prevalence of stages higher than I was significantly higher in PTC patients with BMI ≥ 25 or with metabolic syndrome. Using logistic regression waist circumference ≥ 88 cm in women and ≥102 cm in men, upper tertiles of IL-6 and leptin were associated with a higher clinical stage. There were no differences in the prevalence of microcarcinomas in analyzed groups (BMI ≥ 25 versus BMI
- Subjects :
- medicine.medical_specialty
Article Subject
endocrine system diseases
Endocrinology, Diabetes and Metabolism
Adipokine
030209 endocrinology & metabolism
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Papillary thyroid cancer
03 medical and health sciences
0302 clinical medicine
Endocrinology
Insulin resistance
Internal medicine
Vitamin D and neurology
Medicine
Chemerin
Thyroid cancer
lcsh:RC648-665
biology
Adiponectin
Endocrine and Autonomic Systems
business.industry
medicine.disease
030220 oncology & carcinogenesis
biology.protein
Metabolic syndrome
business
Research Article
Subjects
Details
- ISSN :
- 16878345 and 16878337
- Volume :
- 2018
- Database :
- OpenAIRE
- Journal :
- International Journal of Endocrinology
- Accession number :
- edsair.doi.dedup.....f4a559514eda71651b7ce481d7fae3fa