Back to Search
Start Over
Stroke incidence is highest in women and non-Hispanic blacks living with HIV in the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort
- Source :
- Chow, FC; Wilson, MR; Wu, K; Ellis, RJ; Bosch, RJ; & Linas, BP. (2018). Stroke incidence is highest in women and non-Hispanic blacks living with HIV in the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort.. AIDS (London, England), 32(9), 1125-1135. doi: 10.1097/qad.0000000000001799. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6z42h827, AIDS (London, England), vol 32, iss 9, Chow, FC; Wilson, MR; Wu, K; Ellis, RJ; Bosch, RJ; & Linas, BP. (2018). Stroke incidence is highest in women and non-Hispanic blacks living with HIV in the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort. AIDS, 32(9), 1125-1135. doi: 10.1097/QAD.0000000000001799. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6zs2z06b
- Publication Year :
- 2018
- Publisher :
- eScholarship, University of California, 2018.
-
Abstract
- Author(s): Chow, Felicia C; Wilson, Michael R; Wu, Kunling; Ellis, Ronald J; Bosch, Ronald J; Linas, Benjamin P | Abstract: OBJECTIVE:To investigate the incidence of first-ever stroke/transient ischemic attack (TIA) and associated risk factors in a cohort of persons living with HIV infection (PLWH). DESIGN:Observational cohort study METHODS:We determined incidence rates of first-ever stroke/TIA in PLWH after ART initiation from the AIDS Clinical Trials Group ALLRT cohort and its parent trials. Poisson regression models evaluated baseline and time-varying covariates as risk factors for stroke/TIA. RESULTS:The incidence rate of stroke/TIA was 1.69 per 1000 person-years. Incidence rates were highest in women (2.88 stroke/TIAs per 1000 person-years compared with 1.40 per 1000 person-years in men) and non-Hispanic Blacks (2.51 stroke/TIAs per 1000 person-years compared with 0.77 per 1000 person-years in Hispanic/other race/ethnicities and 1.56 per 1000 person-years in whites). In a multivariable model, we found a significant age-by-sex interaction (P = 0.01). The higher risk of stroke/TIA in women was more pronounced at younger ages, whereas older age conferred a greater increase in stroke/TIA risk in men than women. Other risk factors for stroke/TIA included hypertension, higher LDL, and HIV RNA greater than 200 copies/ml. Overweight/obese BMI and higher CD4+:CD8+ ratio protected against stroke/TIA. CONCLUSION:Women and non-Hispanic Blacks living with HIV had the highest incidence rates of stroke/TIA. A concerted effort must be made to include PLWH from these at-risk groups in observational and interventional studies aimed at understanding stroke mechanisms and reducing stroke risk in HIV infection. Strategies to modify stroke risk in PLWH should employ a multipronged approach targeting vascular risk factors and engaging and retaining patients in HIV care.
- Subjects :
- race disparities
Male
HIV Infections
Overweight
Medical and Health Sciences
law.invention
0302 clinical medicine
Randomized controlled trial
law
Risk Factors
Ethnicity
Immunology and Allergy
Medicine
030212 general & internal medicine
Prospective Studies
Stroke
Randomized Controlled Trials as Topic
Ischemic Attack
Transient
Incidence (epidemiology)
Incidence
Middle Aged
Biological Sciences
cerebrovascular disease
Infectious Diseases
Ischemic Attack, Transient
Cohort
symbols
Female
medicine.symptom
Cohort study
cardiovascular risk
Adult
medicine.medical_specialty
Immunology
Ethnic Groups
Article
03 medical and health sciences
symbols.namesake
Sex Factors
Acquired immunodeficiency syndrome (AIDS)
Internal medicine
Virology
parasitic diseases
Humans
Poisson regression
cardiovascular diseases
business.industry
Psychology and Cognitive Sciences
medicine.disease
HIV infection
sex disparities
nervous system diseases
transient ischemic attack
business
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Chow, FC; Wilson, MR; Wu, K; Ellis, RJ; Bosch, RJ; & Linas, BP. (2018). Stroke incidence is highest in women and non-Hispanic blacks living with HIV in the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort.. AIDS (London, England), 32(9), 1125-1135. doi: 10.1097/qad.0000000000001799. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6z42h827, AIDS (London, England), vol 32, iss 9, Chow, FC; Wilson, MR; Wu, K; Ellis, RJ; Bosch, RJ; & Linas, BP. (2018). Stroke incidence is highest in women and non-Hispanic blacks living with HIV in the AIDS Clinical Trials Group Longitudinal Linked Randomized Trials cohort. AIDS, 32(9), 1125-1135. doi: 10.1097/QAD.0000000000001799. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6zs2z06b
- Accession number :
- edsair.doi.dedup.....f49c3f55dc4e0fc10849f05cdf0c14a9