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A new chiral sulfonamide ligand based on tartaric acid: synthesis and application in the enantioselective addition of diethylzinc to aldehydes and ketones
- Source :
- Tetrahedron: Asymmetry. 17:2101-2107
- Publication Year :
- 2006
- Publisher :
- Elsevier BV, 2006.
-
Abstract
- A new sulfonamide ligand based on l -tartaric acid was synthesized and was employed as a chiral ligand in the enantioselective addition of diethylzinc to aldehydes, giving rise to the best enantiomeric excess up to 83% with 5 mol % of catalyst loading. Moreover, the addition of diethylzinc to ketones can also be achieved with good to excellent enantioselectivities by employing 7 mol % of the catalyst under mild conditions.
- Subjects :
- chemistry.chemical_classification
Addition reaction
Ligand
Organic Chemistry
Chiral ligand
Enantioselective synthesis
General Medicine
Diethylzinc
Combinatorial chemistry
Catalysis
Sulfonamide
Inorganic Chemistry
chemistry.chemical_compound
chemistry
Tartaric acid
Organic chemistry
Physical and Theoretical Chemistry
Enantiomeric excess
Subjects
Details
- ISSN :
- 09574166
- Volume :
- 17
- Database :
- OpenAIRE
- Journal :
- Tetrahedron: Asymmetry
- Accession number :
- edsair.doi.dedup.....f498fa9a4a67621b26f00662a64f3f12