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Tea, obesity, and diabetes
- Source :
- Molecular Nutrition & Food Research. 50:188-210
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- Tea has been found to possess widespread biological functions based on a variety of laboratory data. The effects of tea on obesity and diabetes have received increasing attention. This paper reviews the evidence for the connections among tea catechins, and obesity and diabetes. Tea catechins, especially (-)-epigallocatechin gallate (EGCG), appear to have antiobesity and antidiabetic effects. While few epidemiological and clinical studies show the health benefits of EGCG on obesity and diabetes, the mechanisms of its actions are emerging based on the various laboratory data. These mechanisms may be related to certain pathways, such as through the modulations of energy balance, endocrine systems, food intake, lipid and carbohydrate metabolism, the redox status, and activities of different types of cells (i. e., fat, liver, muscle, and beta-pancreatic cells). Because the EGCG receptor, the so-called 67-kDa laminin receptor (LR), has been discovered with colocalization of other types of LR and cytoskeleton in both cancer cells and normal cells, this may explain that EGCG possesses numerous actions. The mechanistic results of this review may possibly be utilized in the treatment of obesity, diabetes, and other related diseases using tea- and EGCG-based folk medicines.
- Subjects :
- medicine.medical_specialty
Lipolysis
Flavonoid
Apoptosis
Epigallocatechin gallate
Carbohydrate metabolism
complex mixtures
Catechin
Receptors, Laminin
Eating
chemistry.chemical_compound
Internal medicine
Diabetes mellitus
Adipocytes
Diabetes Mellitus
medicine
Animals
Humans
Endocrine system
Obesity
Receptor
chemistry.chemical_classification
Tea
business.industry
Body Weight
Fatty Acids
food and beverages
Cell Differentiation
medicine.disease
Lipids
Hormones
Endocrinology
chemistry
Cancer cell
Energy Metabolism
business
Oxidation-Reduction
Cell Division
Food Science
Biotechnology
Subjects
Details
- ISSN :
- 16134133 and 16134125
- Volume :
- 50
- Database :
- OpenAIRE
- Journal :
- Molecular Nutrition & Food Research
- Accession number :
- edsair.doi.dedup.....f4914f5f3f2a4eddcfb1a429caa815d2