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Risk factors of suicidal ideation in Huntington's disease: literature review and data from Enroll-HD
- Source :
- Journal of neurology. 265(11)
- Publication Year :
- 2018
-
Abstract
- Suicide is a leading cause of death in Huntington’s disease (HD), following pneumonia. Up to one-fifth of individuals with HD report suicidal ideation. Identifying the risk factors of suicidal ideation in this clinical population is thus pivotal. Here, we review the literature on prevalence rates and risk factors of suicidal ideation in premanifest and manifest patients and re-evaluate them using the largest currently existing clinical dataset from the ongoing observational study “Enroll-HD” (N = 5709). Large scale studies yielded important insights regarding suicidal ideation in HD. However, estimated prevalence rates vary among studies and risk factors are still poorly understood. According to the Enroll-HD data, pre- and manifest disease stages are associated with current (5.8–10%) and a history of suicidal ideation (18.6–30.9%). Throughout the course of HD, a history of suicidal ideation and the presence of depressive symptoms were strongly associated with current suicidal ideation. However, while for premanifest individuals, socio-demographics and activities of daily living appear to be important, in manifest patients, suicidal ideation is more closely linked to anxiety, irritability, psychosis, and apathy. These results highlight the importance of treating depressive symptoms in patients with HD and addressing potential suicidal ideation during clinical monitoring. The relevance of risk factors may differ among premanifest and manifest patients.
- Subjects :
- medicine.medical_specialty
Population
Disease
Irritability
Suicidal Ideation
03 medical and health sciences
0302 clinical medicine
Huntington's disease
Risk Factors
medicine
Humans
Apathy
Psychiatry
education
Suicidal ideation
Depression (differential diagnoses)
education.field_of_study
business.industry
medicine.disease
030227 psychiatry
Huntington Disease
Neurology
Anxiety
Neurology (clinical)
medicine.symptom
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14321459
- Volume :
- 265
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Journal of neurology
- Accession number :
- edsair.doi.dedup.....f48e85881c6bf4356ab9debd3351fc3a