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Adjunctive benefits of systemic amoxicillin and metronidazole in non-surgical treatment of generalized aggressive periodontitis: a randomized placebo-controlled clinical trial
- Source :
- Journal of Clinical Periodontology. 32:1096-1107
- Publication Year :
- 2005
- Publisher :
- Wiley, 2005.
-
Abstract
- Background: The objective of this study was to assess the adjunctive clinical effect of the administration of systemic amoxicillin and metronidazole in the non-surgical treatment of generalized aggressive periodontitis (GAP).Methods: Forty-one systemically healthy subjects with GAP were included in this 6-month double-blind, placebo-controlled, randomized clinical trial. Patients received a course of full-mouth non-surgical periodontal treatment delivered over a 24 h period using machine-driven and hand instruments. Test subjects received an adjunctive course of systemic antibiotic consisting of 500 mg amoxicillin and 500 mg metronidazole three times a day for 7 days. Clinical parameters were collected at baseline, and at 2 and 6 months post-treatment.Results: In both the test and the placebo groups, all clinical parameters improved at 2 and 6 months. In deep pockets ( >= 7 mm), the test treatment resulted in an additional 1.4 mm (95% confidence interval 0.8, 2.0 mm) in full-mouth probing pocket depth (PPD) reduction and 1 mm (0.7, 1.3 mm) of life cumulative attachment loss (LCAL) gain at 6 months. In moderate pockets (4-6 mm), the adjunctive benefit was smaller in magnitude: PPD reduction was 0.4 mm (0.1, 0.7 mm) and LCAL gain was 0.5 mm (0.2, 0.8 mm). In addition, the 6-month data showed LCAL gains >= 2 mm at 25% of sites in test patients compared with 16% in placebo (p = 0.028). Similarly, PPD reductions of 2 mm or more were observed in 30% of sites in test and 21% of sites in placebo patients. Seventy-four percent of pockets with PPD >= 5 mm at baseline were 4 mm or shallower at 6 months in the test group. This compared with 54% in the placebo group (p = 0.008). Disease progression at 6 months was observed at 1.5% of test and 3.3% of sites in test and placebo, respectively (p = 0.072).Conclusions: These data indicate that a 7-day adjunctive course of systemic metronidazole and amoxicillin significantly improved the short-term clinical outcomes of full-mouth non-surgical periodontal debridement in subjects with GAP.
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Placebo
Gastroenterology
law.invention
Anti-Infective Agents
Randomized controlled trial
law
Metronidazole
Internal medicine
Periodontal Attachment Loss
medicine
Humans
Periodontal Pocket
Aggressive periodontitis
Periodontitis
business.industry
Amoxicillin
medicine.disease
Confidence interval
Surgery
Clinical trial
Clinical attachment loss
Periodontics
Female
Epidemiologic Methods
business
Algorithms
medicine.drug
Subjects
Details
- ISSN :
- 1600051X and 03036979
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- Journal of Clinical Periodontology
- Accession number :
- edsair.doi.dedup.....f48688b987348b0c8d66c67f5c4f2c9d