Semi-automated validation and quantification of CTLA-4 in 90 different tumor entities using multiple antibodies and artificial intelligence

Authors :: David Dum
Tjark L.C. Henke
Tim Mandelkow
Cheng Yang
Elena Bady
Jonas B. Raedler
Ronald Simon
Guido Sauter
Maximilian Lennartz
Franziska Büscheck
Andreas M. Luebke
Anne Menz
Andrea Hinsch
Doris Höflmayer
Sören Weidemann
Christoph Fraune
Katharina Möller
Patrick Lebok
Ria Uhlig
Christian Bernreuther
Frank Jacobsen
Till S. Clauditz
Waldemar Wilczak
Sarah Minner
Eike Burandt
Stefan Steurer
Niclas C. Blessin
Source :: Laboratory Investigation. 102:650-657
Publication Year :: 2022
Publisher :: Elsevier BV, 2022.
Abstract: CTLA-4 is an inhibitory immune checkpoint receptor and a negative regulator of anti-tumor T-cell function. This study is aimed for a comparative analysis of CTLA-4

Subjects :: Artificial Intelligence
Lymphatic Metastasis
Liver Neoplasms
Humans
CTLA-4 Antigen
Cell Biology
Molecular Biology
Antibodies
B7-H1 Antigen
Pathology and Forensic Medicine

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