An electrochemical sensor for dipyrone determination based on nickel-salen film modified electrode

Made available in DSpace on 2013-09-27T14:53:53Z (GMT). No. of bitstreams: 1 WOS000275995600210.pdf: 171567 bytes, checksum: 8603747737628bbd5ef1b702ec0f6a96 (MD5) Previous issue date: 2009-01-01 Made available in DSpace on 2013-09-30T18:09:38Z (GMT). No. of bitstreams: 1 WOS000275995600210.pdf: 171567 bytes, checksum: 8603747737628bbd5ef1b702ec0f6a96 (MD5) Previous issue date: 2009-01-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:23:13Z No. of bitstreams: 1 WOS000275995600210.pdf: 171567 bytes, checksum: 8603747737628bbd5ef1b702ec0f6a96 (MD5) Made available in DSpace on 2014-05-20T13:23:13Z (GMT). No. of bitstreams: 1 WOS000275995600210.pdf: 171567 bytes, checksum: 8603747737628bbd5ef1b702ec0f6a96 (MD5) Previous issue date: 2009-01-01 An amperometric dipyrone sensor based on a polymeric nickel-salen (salen = N,N'-ethylenebis(salicydeneiminato)) film coated platinum electrode was developed. The sensor was constructed by electropolymerization of nickel-salen complex at a platinum electrode in acetonitrile/tetrabuthylamonium perchlorate by cyclic voltammetry. After cycling the modified electrode in a 0.50 mol L-1 KCl solution, the estimated surface concentration was found to be equal to 1.29 x 10(-9) mol cm(-2). This is a typical behavior of an electrode surface immobilized with a redox couple that can usually be considered as a reversible single-electron reduction/oxidation of the nickel(II)/nickel(III) couple. A plot of the anodic current versus the dipyrone concentration for chronoamperometry (potential fixed = +0.50 V) at the sensor was linear in the 4.7 x 10(-6) to 1.1 x 10(-4) mol L-1 concentration range and the concentration limit was 1.2 x 10(-6) mol L-1. The proposed electrode is useful for the quality control and routine analysis of dipyrone in pharmaceutical formulations. Univ State São Paulo UNESP, Dept Phys Chem & Biol, Fac Sci & Technol, Presidente Prudente, SP, Brazil Univ State São Paulo UNESP, Dept Phys Chem & Biol, Fac Sci & Technol, Presidente Prudente, SP, Brazil