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Bipolar Electrochemical Measurement of Enantiomeric Excess with Inherently Chiral Polymer Actuators
- Source :
- ACS Measurement Science Au, Vol 1, Iss 3, Pp 110-116 (2021), ACS Measurement Science Au, ACS Measurement Science Au, 2021, 1 (3), pp.110-116. ⟨10.1021/acsmeasuresciau.1c00011⟩
- Publication Year :
- 2021
- Publisher :
- American Chemical Society, 2021.
-
Abstract
- International audience; Straightforward enantioselective analytical methods are very important for drug safety, considering that in certain cases one of the two enantiomers of a chiral molecule might be harmful for humans. In this work, we propose a simple system for the direct and easy read-out of the enantiomeric excess of 3,4-dihydroxyphenylalanine (DOPA) as a model analyte. A conducting oligomer, i.e. oligo-(3,3′-dibenzothiophene), bearing inherently chiral features, is electrogenerated on a polypyrrole film. The resulting freestanding hybrid material is used as a wireless enantioselective actuator in a bipolar electrochemical cell. Combining in a single setup two individual actuators with opposite chiral features allows a direct visual read-out of enantiomeric excess, as the bending amplitude of each of the two actuators is directly correlated with the concentration of the corresponding stereoisomer of the analyte. Optimization of the experimental parameters results in efficient bending, giving access to the percentage values of the enantiomeric excess in mixtures containing different ratios of the antipodes, thus opening the way to potential applications for chiral in situ analysis.
- Subjects :
- Environmental Engineering
Materials science
02 engineering and technology
010402 general chemistry
Electrochemistry
01 natural sciences
Article
Industrial and Manufacturing Engineering
Absolute Enantiodiscrimination
Metrics & More Article Recommendations Electrochemical Actuators
Bipolar Electrochemistry
[CHIM]Chemical Sciences
Electrochemical Actuators
Enantiomeric excess
chemistry.chemical_classification
QD71-142
Polymer
021001 nanoscience & nanotechnology
0104 chemical sciences
Chemical engineering
chemistry
Direct Enantiomeric Excess Determination
Inherent Chirality
0210 nano-technology
Actuator
Analytical chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 2694250X
- Volume :
- 1
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- ACS Measurement Science Au
- Accession number :
- edsair.doi.dedup.....f467d035b306bf64996442f3e12bd66c