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Biochemical evidence of platelet activation in patients with persistent unstable angina
- Source :
- Journal of the American College of Cardiology. 10(5)
- Publication Year :
- 1987
-
Abstract
- Thromboxane released from activated platelets and prostacyclin of the vessel wall may act as potent antagonistic modulators of platelet aggregability and coronary vascular tone. Therefore, urinary excretion of their major metabolites, 2,3-dinor-thromboxane B2 and 2,3-dinor-6-ketoprostaglandin F1 alpha, was studied in 16 patients presenting with prolonged angina at rest. The 10 patients whose condition did not improve under vigorous antianginal treatment within 48 hours exhibited higher thromboxane metabolite excretion than did the 6 patients who responded to therapy (2,208 +/- 1,542 versus 609 +/- 312 ng/g creatinine; p less than 0.001). Elevated values were also found in four of eight patients with sustained postinfarction angina. Enhanced thromboxane metabolite excretion was frequently associated with angiographic evidence of thrombus formation. When nine patients were restudied in a stable phase after 11 +/- 5 months, thromboxane metabolite excretion was consistently normal or high normal. Excretion of prostacyclin metabolites was not depressed in any patient but correlated weakly with thromboxane (r = 0.41). Thus, enhanced thromboxane production as an index of platelet activation may identify patients with active thrombus formation who could benefit most from platelet inhibitory treatment.
- Subjects :
- Male
medicine.medical_specialty
Platelet Aggregation
Thromboxane
Metabolite
Prostacyclin
6-Ketoprostaglandin F1 alpha
Angina Pectoris
Excretion
Thromboxane Production
chemistry.chemical_compound
Electrocardiography
Internal medicine
medicine
Humans
Platelet
Platelet activation
Angina, Unstable
Aged
Monitoring, Physiologic
Unstable angina
business.industry
Middle Aged
medicine.disease
Thromboxane B2
Endocrinology
chemistry
Exercise Test
Female
business
Cardiology and Cardiovascular Medicine
medicine.drug
Follow-Up Studies
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 10
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....f4656bf6e595b708dd16a4638df6c380