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Effect of high population density environment on skin barrier function in mice
- Source :
- Journal of dermatological science. 25(3)
- Publication Year :
- 2001
-
Abstract
- Previous reports have demonstrated that stressful stimuli markedly influenced physiological conditions and homeostasis. In this study, we examined the influence of high population density environment on barrier function and water retention property of skin in mice. Overcrowding stress induced dramatic body weight reduction and significant increase in adrenal gland weight. Macroscopic skin appearance showed moderate exfoliation and slight wrinkle formation in the stress group. Moreover epidermis hyperplasia not concomitant with inflammatory reactions such as infiltration of immunocytes and vasodilation was observed in the skin from the stress group. Skin surface conductance in the stress group was significantly lower than in the control group. On the other hand, transepidermal water loss in the stress group increased significantly, compared to the control group. Moreover, transdermal penetration of indomethacin and nicotinic acid amide was enhanced significantly. These results suggest that overcrowding stress induced impairment of barrier function and water retention property. To elucidate the mechanism of overcrowding stress-induce dry skin, contents of ceramide and pyrrolidone carboxylic acid, which are the important compounds contributing to those functions were evaluated. Both of them in stratum corneum declined significantly in the stress group. Taken together, these results demonstrate that overcrowding stress induced dry skin, and that the impairment of barrier function and water retention property correlated with decrease in ceramide and pyrrolidone carboxylic acid.
- Subjects :
- Male
Ceramide
medicine.medical_specialty
Dermatology
Environment
Ceramides
Biochemistry
chemistry.chemical_compound
Mice
Body Water
Stress, Physiological
Internal medicine
Skin Physiological Phenomena
Dry skin
Adrenal Glands
Weight Loss
medicine
Stratum corneum
Animals
Molecular Biology
Wrinkle
Barrier function
Population Density
Transepidermal water loss
Mice, Inbred BALB C
integumentary system
Organ Size
Pyrrolidonecarboxylic Acid
medicine.anatomical_structure
Endocrinology
chemistry
Epidermis
medicine.symptom
Subjects
Details
- ISSN :
- 09231811
- Volume :
- 25
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Journal of dermatological science
- Accession number :
- edsair.doi.dedup.....f44b64f9b9a9b465ea5f3759bece95e2