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Evidence for a mitochondrial impact of trimetazidine during cold ischemia and reperfusion
- Source :
- Pharmacology. 71(1)
- Publication Year :
- 2003
-
Abstract
- In organ transplantation, ischemia-reperfusion injury (IRI) has been implicated in delayed graft function (DGF) as well as in short- and long-term complications. Using an autotransplant pig kidney model, changes in renal function and morphology were determined after different periods of cold ischemia in kidneys preserved in the University of Wisconsin solution (UW), high-Na+ version of UW (HEH) or Celsior (CEL) a newly developed high-Na+ solution, with or without trimetazidine (TMZ). Kidney function was better preserved in CEL, UW and particularly HEH in combination with TMZ, particularly after 48 and 72 h. Mitochondria integrity was improved in TMZ-preserved groups. This study indicates that TMZ is efficiently protective against IRI even after prolonged preservation and in different preservation solutions.
- Subjects :
- medicine.medical_specialty
Adenosine
Time Factors
Swine
medicine.medical_treatment
Allopurinol
Organ Preservation Solutions
Trimetazidine
Urology
Drug Evaluation, Preclinical
Renal function
Disaccharides
Kidney Function Tests
Transplantation, Autologous
Organ transplantation
Electrolytes
Raffinose
Glutamates
medicine
Animals
Insulin
Viaspan
Histidine
Mannitol
Kidney transplantation
Pharmacology
Cryopreservation
business.industry
General Medicine
Organ Preservation
medicine.disease
Receptors, GABA-A
Glutathione
Kidney Transplantation
Mitochondria
Disease Models, Animal
Anesthesia
Reperfusion Injury
business
Reperfusion injury
Biomarkers
medicine.drug
Subjects
Details
- ISSN :
- 00317012
- Volume :
- 71
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pharmacology
- Accession number :
- edsair.doi.dedup.....f444b071da66153072752b442f18993a