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The Influence of Sarin on Various Physiological Functions in Rats Following Single or Repeated Low-Level Inhalation Exposure
- Source :
- Inhalation Toxicology. 16:517-530
- Publication Year :
- 2004
- Publisher :
- Informa UK Limited, 2004.
-
Abstract
- Long-term effects of low doses of highly toxic organophosphorus agent sarin on various hematological and biochemical markers and physiological functions were studied in rats exposed to sarin by inhalation. The results indicate that low-level sarin-exposed rats show long-term increase in studied markers of stress and decrease in synthesis of DNA de novo without the disturbance of the functions of cholinergic nervous system. Moreover, sarin at low doses is able to induce some neurotoxic effects including an increase in the excitability of central nervous system in rats at 3 mo following inhalation exposure. Relatively long-term spatial discrimination impairments in rats exposed to low-level sarin was demonstrated too. Therefore, nerve agents such as sarin seem to be harmful not only at high, clinically symptomatic doses but also at low doses without acute clinical manifestation of overstimulation of cholinergic nervous system because of long-term manifestation of alteration of neurophysiological and neurobehavioral functions in sarin-exposed rats.
- Subjects :
- DNA Replication
Male
Nervous system
Sarin
Erythrocytes
Time Factors
Health, Toxicology and Mutagenesis
Central nervous system
Clinical Chemistry Tests
Pharmacology
Toxicology
chemistry.chemical_compound
Administration, Inhalation
medicine
Animals
Nervous System Physiological Phenomena
Chemical Warfare Agents
Nerve agent
Inhalation exposure
Inhalation Exposure
Hematologic Tests
Behavior, Animal
Dose-Response Relationship, Drug
DNA synthesis
Inhalation
Chemistry
Rats
Specific Pathogen-Free Organisms
medicine.anatomical_structure
Liver
Cholinergic
Cholinesterase Inhibitors
medicine.drug
Subjects
Details
- ISSN :
- 10917691 and 08958378
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Inhalation Toxicology
- Accession number :
- edsair.doi.dedup.....f4359c6684c34ae2c95d46b6586c88ac